GABAergic inhibition in the human visual cortex relates to eye dominance

Abstract Binocular vision is created by fusing the separate inputs arriving from the left and right eyes. ‘Eye dominance’ provides a measure of the perceptual dominance of one eye over the other. Theoretical models suggest that eye dominance is related to reciprocal inhibition between monocular unit...

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Autores principales:	I. Betina Ip, Uzay E. Emir, Claudia Lunghi, Andrew J. Parker, Holly Bridge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14cc4bdb3c894ef6a2550908606f0c44
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spelling	oai:doaj.org-article:14cc4bdb3c894ef6a2550908606f0c442021-12-02T18:53:08ZGABAergic inhibition in the human visual cortex relates to eye dominance10.1038/s41598-021-95685-12045-2322https://doaj.org/article/14cc4bdb3c894ef6a2550908606f0c442021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95685-1https://doaj.org/toc/2045-2322Abstract Binocular vision is created by fusing the separate inputs arriving from the left and right eyes. ‘Eye dominance’ provides a measure of the perceptual dominance of one eye over the other. Theoretical models suggest that eye dominance is related to reciprocal inhibition between monocular units in the primary visual cortex, the first location where the binocular input is combined. As the specific inhibitory interactions in the binocular visual system critically depend on the presence of visual input, we sought to test the role of inhibition by measuring the inhibitory neurotransmitter GABA during monocular visual stimulation of the dominant and the non-dominant eye. GABA levels were measured in a single volume of interest in the early visual cortex, including V1 from both hemispheres, using a combined functional magnetic resonance imaging and magnetic resonance spectroscopy (combined fMRI-MRS) sequence on a 7-Tesla MRI scanner. Individuals with stronger eye dominance had a greater difference in GABAergic inhibition between the eyes. This relationship was present only when the visual system was actively processing sensory input and was not present at rest. We provide the first evidence that imbalances in GABA levels during ongoing sensory processing are related to eye dominance in the human visual cortex. Our finding supports the view that intracortical inhibition underlies normal eye dominance.I. Betina IpUzay E. EmirClaudia LunghiAndrew J. ParkerHolly BridgeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I. Betina Ip Uzay E. Emir Claudia Lunghi Andrew J. Parker Holly Bridge GABAergic inhibition in the human visual cortex relates to eye dominance
description	Abstract Binocular vision is created by fusing the separate inputs arriving from the left and right eyes. ‘Eye dominance’ provides a measure of the perceptual dominance of one eye over the other. Theoretical models suggest that eye dominance is related to reciprocal inhibition between monocular units in the primary visual cortex, the first location where the binocular input is combined. As the specific inhibitory interactions in the binocular visual system critically depend on the presence of visual input, we sought to test the role of inhibition by measuring the inhibitory neurotransmitter GABA during monocular visual stimulation of the dominant and the non-dominant eye. GABA levels were measured in a single volume of interest in the early visual cortex, including V1 from both hemispheres, using a combined functional magnetic resonance imaging and magnetic resonance spectroscopy (combined fMRI-MRS) sequence on a 7-Tesla MRI scanner. Individuals with stronger eye dominance had a greater difference in GABAergic inhibition between the eyes. This relationship was present only when the visual system was actively processing sensory input and was not present at rest. We provide the first evidence that imbalances in GABA levels during ongoing sensory processing are related to eye dominance in the human visual cortex. Our finding supports the view that intracortical inhibition underlies normal eye dominance.
format	article
author	I. Betina Ip Uzay E. Emir Claudia Lunghi Andrew J. Parker Holly Bridge
author_facet	I. Betina Ip Uzay E. Emir Claudia Lunghi Andrew J. Parker Holly Bridge
author_sort	I. Betina Ip
title	GABAergic inhibition in the human visual cortex relates to eye dominance
title_short	GABAergic inhibition in the human visual cortex relates to eye dominance
title_full	GABAergic inhibition in the human visual cortex relates to eye dominance
title_fullStr	GABAergic inhibition in the human visual cortex relates to eye dominance
title_full_unstemmed	GABAergic inhibition in the human visual cortex relates to eye dominance
title_sort	gabaergic inhibition in the human visual cortex relates to eye dominance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14cc4bdb3c894ef6a2550908606f0c44
work_keys_str_mv	AT ibetinaip gabaergicinhibitioninthehumanvisualcortexrelatestoeyedominance AT uzayeemir gabaergicinhibitioninthehumanvisualcortexrelatestoeyedominance AT claudialunghi gabaergicinhibitioninthehumanvisualcortexrelatestoeyedominance AT andrewjparker gabaergicinhibitioninthehumanvisualcortexrelatestoeyedominance AT hollybridge gabaergicinhibitioninthehumanvisualcortexrelatestoeyedominance
_version_	1718377309806788608

GABAergic inhibition in the human visual cortex relates to eye dominance

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