Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in ICB in relapsed SCLC.

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Autores principales:	Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff63101
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spelling	oai:doaj.org-article:14cd7395b4e240a6a4c5e9753ff631012021-12-02T18:02:51ZNotch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer10.1038/s41467-021-24164-y2041-1723https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff631012021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24164-yhttps://doaj.org/toc/2041-1723Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in ICB in relapsed SCLC.Nitin RoperMoises J. VelezAlberto ChiapporiYoo Sun KimJun S. WeiSivasish SindiriNobuyuki TakahashiDeborah MulfordSuresh KumarKris YlayaChristopher TrindadeIrena ManukyanAnna-Leigh BrownJane B. TrepelJung-Min LeeStephen HewittJaved KhanAnish ThomasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nitin Roper Moises J. Velez Alberto Chiappori Yoo Sun Kim Jun S. Wei Sivasish Sindiri Nobuyuki Takahashi Deborah Mulford Suresh Kumar Kris Ylaya Christopher Trindade Irena Manukyan Anna-Leigh Brown Jane B. Trepel Jung-Min Lee Stephen Hewitt Javed Khan Anish Thomas Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
description	Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in ICB in relapsed SCLC.
format	article
author	Nitin Roper Moises J. Velez Alberto Chiappori Yoo Sun Kim Jun S. Wei Sivasish Sindiri Nobuyuki Takahashi Deborah Mulford Suresh Kumar Kris Ylaya Christopher Trindade Irena Manukyan Anna-Leigh Brown Jane B. Trepel Jung-Min Lee Stephen Hewitt Javed Khan Anish Thomas
author_facet	Nitin Roper Moises J. Velez Alberto Chiappori Yoo Sun Kim Jun S. Wei Sivasish Sindiri Nobuyuki Takahashi Deborah Mulford Suresh Kumar Kris Ylaya Christopher Trindade Irena Manukyan Anna-Leigh Brown Jane B. Trepel Jung-Min Lee Stephen Hewitt Javed Khan Anish Thomas
author_sort	Nitin Roper
title	Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
title_short	Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
title_full	Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
title_fullStr	Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
title_full_unstemmed	Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
title_sort	notch signaling and efficacy of pd-1/pd-l1 blockade in relapsed small cell lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff63101
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Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

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