Pathophysiology of hyperuricemia and its clinical significance – a narrative review
Hyperuricemia, i.e. increased serum uric acid (UA) concentration, is a common problem in clinical practice. While there are clear guidelines concerning management of symptomatic hyperuricemia in acute conditions such as gout, urolithiasis or acute urate nephropathy, less is known about their seconda...
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Termedia Publishing House
2020
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oai:doaj.org-article:14cddbf04f6147bab96ffc117b2152652021-12-02T18:54:24ZPathophysiology of hyperuricemia and its clinical significance – a narrative review0034-62332084-983410.5114/reum.2020.100140https://doaj.org/article/14cddbf04f6147bab96ffc117b2152652020-10-01T00:00:00Zhttps://www.termedia.pl/Pathophysiology-of-hyperuricemia-and-its-clinical-significance-a-narrative-review,18,42150,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Hyperuricemia, i.e. increased serum uric acid (UA) concentration, is a common problem in clinical practice. While there are clear guidelines concerning management of symptomatic hyperuricemia in acute conditions such as gout, urolithiasis or acute urate nephropathy, less is known about their secondary prevention. Moreover, despite the ongoing debate on the role of UA in the pathogenesis of chronic kidney disease, hypertension, cardiovascular disease and heart failure, the management of asymptomatic hyperuricemia in patients with these chronic conditions is still mainly up to physicians’ judgement. Individual considerations should always be taken into account when prescribing urate-lowering therapy. In this narrative review study, we attempt to present current trends concerning treatment of patients with either symptomatic or asymptomatic hyperuricemia in the light of the available knowledge on the role of hyperuricemia in the development of gout, renal, cardiovascular and other diseases.Marta SkoczyńskaMałgorzata ChowaniecAnna SzymczakAnna Langner-HetmańczukBeata Maciążek-ChyraPiotr WilandTermedia Publishing Housearticlecomorbidity hyperuricemia uric acid urate-lowering therapy.MedicineRENRheumatology, Vol 58, Iss 5, Pp 312-323 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
comorbidity hyperuricemia uric acid urate-lowering therapy. Medicine R |
| spellingShingle |
comorbidity hyperuricemia uric acid urate-lowering therapy. Medicine R Marta Skoczyńska Małgorzata Chowaniec Anna Szymczak Anna Langner-Hetmańczuk Beata Maciążek-Chyra Piotr Wiland Pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| description |
Hyperuricemia, i.e. increased serum uric acid (UA) concentration, is a common problem in clinical practice. While there are clear guidelines concerning management of symptomatic hyperuricemia in acute conditions such as gout, urolithiasis or acute urate nephropathy, less is known about their secondary prevention. Moreover, despite the ongoing debate on the role of UA in the pathogenesis of chronic kidney disease, hypertension, cardiovascular disease and heart failure, the management of asymptomatic hyperuricemia in patients with these chronic conditions is still mainly up to physicians’ judgement. Individual considerations should always be taken into account when prescribing urate-lowering therapy.
In this narrative review study, we attempt to present current trends concerning treatment of patients with either symptomatic or asymptomatic hyperuricemia in the light of the available knowledge on the role of hyperuricemia in the development of gout, renal, cardiovascular and other diseases. |
| format |
article |
| author |
Marta Skoczyńska Małgorzata Chowaniec Anna Szymczak Anna Langner-Hetmańczuk Beata Maciążek-Chyra Piotr Wiland |
| author_facet |
Marta Skoczyńska Małgorzata Chowaniec Anna Szymczak Anna Langner-Hetmańczuk Beata Maciążek-Chyra Piotr Wiland |
| author_sort |
Marta Skoczyńska |
| title |
Pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| title_short |
Pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| title_full |
Pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| title_fullStr |
Pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| title_full_unstemmed |
Pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| title_sort |
pathophysiology of hyperuricemia and its clinical significance – a narrative review |
| publisher |
Termedia Publishing House |
| publishDate |
2020 |
| url |
https://doaj.org/article/14cddbf04f6147bab96ffc117b215265 |
| work_keys_str_mv |
AT martaskoczynska pathophysiologyofhyperuricemiaanditsclinicalsignificanceanarrativereview AT małgorzatachowaniec pathophysiologyofhyperuricemiaanditsclinicalsignificanceanarrativereview AT annaszymczak pathophysiologyofhyperuricemiaanditsclinicalsignificanceanarrativereview AT annalangnerhetmanczuk pathophysiologyofhyperuricemiaanditsclinicalsignificanceanarrativereview AT beatamaciazekchyra pathophysiologyofhyperuricemiaanditsclinicalsignificanceanarrativereview AT piotrwiland pathophysiologyofhyperuricemiaanditsclinicalsignificanceanarrativereview |
| _version_ |
1718377310001823744 |