High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review

Globally, prostate cancer (PCa) is the second most preponderant cancer in men. It contributes to the high mortality-to-incidence ratio reported in West Africa and Asia largely due to low screening. The mortality risk is determined or predicted based on the prevalence of high-risk or aggressive PCa u...

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Autor principal:	Jude O Okoye
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2020
Materias:	gleason grade gleason system mortality risk prostate cancer psa level Medicine R
Acceso en línea:	https://doaj.org/article/14cef87036b34fc1a1f2adee6ce42d04
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spelling	oai:doaj.org-article:14cef87036b34fc1a1f2adee6ce42d042021-12-02T18:42:19ZHigh mortality risk of prostate cancer patients in Asia and West Africa: A systematic review2231-07702249-446410.4103/AJM.AJM_19_20https://doaj.org/article/14cef87036b34fc1a1f2adee6ce42d042020-07-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/AJM.AJM_19_20https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Globally, prostate cancer (PCa) is the second most preponderant cancer in men. It contributes to the high mortality-to-incidence ratio reported in West Africa and Asia largely due to low screening. The mortality risk is determined or predicted based on the prevalence of high-risk or aggressive PCa using a scoring or grading system such as Gleason score (GS), Gleason grade (GG), and prostate-specific antigen (PSA) level. In this review, peer-reviewed articles found on databases such as Google Scholar, Scopus, Web of Science, PubMed Central and, EMBASE were selected based on adherence to clinical guidelines for the classification of PCa. In West Africa and Asia, the result revealed that the frequency of high-risk PCa was 42% and 51.2% based on GS, 48.8% and 25.3% based on GG pattern, and 87.5% and 44.3% based on PSA level >10 ng/mL, respectively. Data revealed a high prevalence of high-risk PCa both in West Africa and Asia when compared with developed countries. However, the prevalence of high-risk PCa is higher in West Africa than in Asia. Studies have shown that high-risk PCas are associated with germline mutations and such mutations are prevalent in blacks and Asians than in whites. Thus, testing for germline mutations in patients with GS of ≥ 7, GG ≥ 3, high prostate density, low prostate volume, and PSA levels of >4.0 ng/mL may identify those at risk of developing lethal PCa and could reduce the mortality rates in Asia and West Africa.Jude O OkoyeThieme Medical and Scientific Publishers Pvt. Ltd.articlegleason gradegleason systemmortality riskprostate cancerpsa levelMedicineRENAvicenna Journal of Medicine, Vol 10, Iss 03, Pp 93-101 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gleason grade gleason system mortality risk prostate cancer psa level Medicine R
spellingShingle	gleason grade gleason system mortality risk prostate cancer psa level Medicine R Jude O Okoye High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review
description	Globally, prostate cancer (PCa) is the second most preponderant cancer in men. It contributes to the high mortality-to-incidence ratio reported in West Africa and Asia largely due to low screening. The mortality risk is determined or predicted based on the prevalence of high-risk or aggressive PCa using a scoring or grading system such as Gleason score (GS), Gleason grade (GG), and prostate-specific antigen (PSA) level. In this review, peer-reviewed articles found on databases such as Google Scholar, Scopus, Web of Science, PubMed Central and, EMBASE were selected based on adherence to clinical guidelines for the classification of PCa. In West Africa and Asia, the result revealed that the frequency of high-risk PCa was 42% and 51.2% based on GS, 48.8% and 25.3% based on GG pattern, and 87.5% and 44.3% based on PSA level >10 ng/mL, respectively. Data revealed a high prevalence of high-risk PCa both in West Africa and Asia when compared with developed countries. However, the prevalence of high-risk PCa is higher in West Africa than in Asia. Studies have shown that high-risk PCas are associated with germline mutations and such mutations are prevalent in blacks and Asians than in whites. Thus, testing for germline mutations in patients with GS of ≥ 7, GG ≥ 3, high prostate density, low prostate volume, and PSA levels of >4.0 ng/mL may identify those at risk of developing lethal PCa and could reduce the mortality rates in Asia and West Africa.
format	article
author	Jude O Okoye
author_facet	Jude O Okoye
author_sort	Jude O Okoye
title	High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review
title_short	High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review
title_full	High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review
title_fullStr	High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review
title_full_unstemmed	High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review
title_sort	high mortality risk of prostate cancer patients in asia and west africa: a systematic review
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2020
url	https://doaj.org/article/14cef87036b34fc1a1f2adee6ce42d04
work_keys_str_mv	AT judeookoye highmortalityriskofprostatecancerpatientsinasiaandwestafricaasystematicreview
_version_	1718377723768864768

High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review

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