Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

Oncolytic viruses induce a variety of immune targets in the infected tumours. Here, the authors show that Newcastle Disease Virus (NDV) upregulates the inducible co-stimulator (ICOS) on T cells and that intratumoral targeting of ICOS with engineered NDV in combination with CTLA-4 blockade induces sy...

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Autores principales:	Dmitriy Zamarin, Rikke B. Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D. Wolchok, James P. Allison
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14d00d2c8ae14d72b432b19c11c9bf8b
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spelling	oai:doaj.org-article:14d00d2c8ae14d72b432b19c11c9bf8b2021-12-02T15:38:55ZIntratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity10.1038/ncomms143402041-1723https://doaj.org/article/14d00d2c8ae14d72b432b19c11c9bf8b2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14340https://doaj.org/toc/2041-1723Oncolytic viruses induce a variety of immune targets in the infected tumours. Here, the authors show that Newcastle Disease Virus (NDV) upregulates the inducible co-stimulator (ICOS) on T cells and that intratumoral targeting of ICOS with engineered NDV in combination with CTLA-4 blockade induces systemic anti-tumour immunity in mice.Dmitriy ZamarinRikke B. HolmgaardJacob RiccaTamar PlittPeter PalesePadmanee SharmaTaha MerghoubJedd D. WolchokJames P. AllisonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dmitriy Zamarin Rikke B. Holmgaard Jacob Ricca Tamar Plitt Peter Palese Padmanee Sharma Taha Merghoub Jedd D. Wolchok James P. Allison Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
description	Oncolytic viruses induce a variety of immune targets in the infected tumours. Here, the authors show that Newcastle Disease Virus (NDV) upregulates the inducible co-stimulator (ICOS) on T cells and that intratumoral targeting of ICOS with engineered NDV in combination with CTLA-4 blockade induces systemic anti-tumour immunity in mice.
format	article
author	Dmitriy Zamarin Rikke B. Holmgaard Jacob Ricca Tamar Plitt Peter Palese Padmanee Sharma Taha Merghoub Jedd D. Wolchok James P. Allison
author_facet	Dmitriy Zamarin Rikke B. Holmgaard Jacob Ricca Tamar Plitt Peter Palese Padmanee Sharma Taha Merghoub Jedd D. Wolchok James P. Allison
author_sort	Dmitriy Zamarin
title	Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
title_short	Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
title_full	Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
title_fullStr	Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
title_full_unstemmed	Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
title_sort	intratumoral modulation of the inducible co-stimulator icos by recombinant oncolytic virus promotes systemic anti-tumour immunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14d00d2c8ae14d72b432b19c11c9bf8b
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Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

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