The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster

Cellular transport and function are dependent on substrate influx and efflux of various compounds. In humans, the largest superfamily of transporters is the SoLute Carriers (SLCs). Many transporters are orphans and little to nothing is known about their expression and/or function, yet they have been...

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Autores principales:	Mikaela M. Ceder, Frida A. Lindberg, Emelie Perland, Michael J. Williams, Robert Fredriksson
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	solute carrier MFS MFSD11 CG18549 drosophila melanogaster locomotion Science Q
Acceso en línea:	https://doaj.org/article/14da0473b00842a7ac8a54d4a8d22745
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spelling	oai:doaj.org-article:14da0473b00842a7ac8a54d4a8d227452021-11-25T17:59:53ZThe Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster10.3390/insects121110242075-4450https://doaj.org/article/14da0473b00842a7ac8a54d4a8d227452021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4450/12/11/1024https://doaj.org/toc/2075-4450Cellular transport and function are dependent on substrate influx and efflux of various compounds. In humans, the largest superfamily of transporters is the SoLute Carriers (SLCs). Many transporters are orphans and little to nothing is known about their expression and/or function, yet they have been assigned to a cluster called atypical SLCs. One of these atypical SLCs is MFSD11. Here we present a first in-depth characterization of the MFSD11, CG18549. By gene expression and behavior analysis on ubiquitous and brain-specific knockdown flies. <i>CG18549</i> knockdown flies were found to have altered adipokinetic hormone and adipokinteic hormone receptor expression as well as reduced vesicular monoamine transporter expression; to exhibit an altered locomotor behavior, and to have an altered reaction to stress stimuli. Furthermore, the gene expression of <i>CG18549</i> in the brain was visualized and abundant expression in both the larvae and adult brain was observed, a result that is coherent with the FlyAtlas Anatomy microarray. The exact mechanism behind the observed behaviors is not fully understood, but this study provides new insights into the expression and function of <i>CG18549</i>. Clearly, these results provide a strong example as to why it is vital to fully characterize orphan transporters and through that gain knowledge about the body during normal condition and disease.Mikaela M. CederFrida A. LindbergEmelie PerlandMichael J. WilliamsRobert FredrikssonMDPI AGarticlesolute carrierMFSMFSD11CG18549drosophila melanogasterlocomotionScienceQENInsects, Vol 12, Iss 1024, p 1024 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	solute carrier MFS MFSD11 CG18549 drosophila melanogaster locomotion Science Q
spellingShingle	solute carrier MFS MFSD11 CG18549 drosophila melanogaster locomotion Science Q Mikaela M. Ceder Frida A. Lindberg Emelie Perland Michael J. Williams Robert Fredriksson The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
description	Cellular transport and function are dependent on substrate influx and efflux of various compounds. In humans, the largest superfamily of transporters is the SoLute Carriers (SLCs). Many transporters are orphans and little to nothing is known about their expression and/or function, yet they have been assigned to a cluster called atypical SLCs. One of these atypical SLCs is MFSD11. Here we present a first in-depth characterization of the MFSD11, CG18549. By gene expression and behavior analysis on ubiquitous and brain-specific knockdown flies. <i>CG18549</i> knockdown flies were found to have altered adipokinetic hormone and adipokinteic hormone receptor expression as well as reduced vesicular monoamine transporter expression; to exhibit an altered locomotor behavior, and to have an altered reaction to stress stimuli. Furthermore, the gene expression of <i>CG18549</i> in the brain was visualized and abundant expression in both the larvae and adult brain was observed, a result that is coherent with the FlyAtlas Anatomy microarray. The exact mechanism behind the observed behaviors is not fully understood, but this study provides new insights into the expression and function of <i>CG18549</i>. Clearly, these results provide a strong example as to why it is vital to fully characterize orphan transporters and through that gain knowledge about the body during normal condition and disease.
format	article
author	Mikaela M. Ceder Frida A. Lindberg Emelie Perland Michael J. Williams Robert Fredriksson
author_facet	Mikaela M. Ceder Frida A. Lindberg Emelie Perland Michael J. Williams Robert Fredriksson
author_sort	Mikaela M. Ceder
title	The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
title_short	The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
title_full	The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
title_fullStr	The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
title_full_unstemmed	The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster
title_sort	fly homologue of mfsd11 is possibly linked to nutrient homeostasis and has a potential role in locomotion: a first characterization of the atypical solute carrier cg18549 in drosophila melanogaster
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/14da0473b00842a7ac8a54d4a8d22745
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The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster

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