TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.

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Autores principales: Nicole Maloney Belle, Yingbiao Ji, Karl Herbine, Yun Wei, JoonHyung Park, Kelly Zullo, Li-Yin Hung, Sriram Srivatsa, Tanner Young, Taylor Oniskey, Christopher Pastore, Wildaliz Nieves, Ma Somsouk, De’Broski R. Herbert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/14dea147249543ad842b96b14c99cd1b
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spelling oai:doaj.org-article:14dea147249543ad842b96b14c99cd1b2021-12-02T17:01:54ZTFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths10.1038/s41467-019-12315-12041-1723https://doaj.org/article/14dea147249543ad842b96b14c99cd1b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12315-1https://doaj.org/toc/2041-1723TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.Nicole Maloney BelleYingbiao JiKarl HerbineYun WeiJoonHyung ParkKelly ZulloLi-Yin HungSriram SrivatsaTanner YoungTaylor OniskeyChristopher PastoreWildaliz NievesMa SomsoukDe’Broski R. HerbertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nicole Maloney Belle
Yingbiao Ji
Karl Herbine
Yun Wei
JoonHyung Park
Kelly Zullo
Li-Yin Hung
Sriram Srivatsa
Tanner Young
Taylor Oniskey
Christopher Pastore
Wildaliz Nieves
Ma Somsouk
De’Broski R. Herbert
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
description TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.
format article
author Nicole Maloney Belle
Yingbiao Ji
Karl Herbine
Yun Wei
JoonHyung Park
Kelly Zullo
Li-Yin Hung
Sriram Srivatsa
Tanner Young
Taylor Oniskey
Christopher Pastore
Wildaliz Nieves
Ma Somsouk
De’Broski R. Herbert
author_facet Nicole Maloney Belle
Yingbiao Ji
Karl Herbine
Yun Wei
JoonHyung Park
Kelly Zullo
Li-Yin Hung
Sriram Srivatsa
Tanner Young
Taylor Oniskey
Christopher Pastore
Wildaliz Nieves
Ma Somsouk
De’Broski R. Herbert
author_sort Nicole Maloney Belle
title TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_short TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_full TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_fullStr TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_full_unstemmed TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
title_sort tff3 interacts with lingo2 to regulate egfr activation for protection against colitis and gastrointestinal helminths
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/14dea147249543ad842b96b14c99cd1b
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