SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes

miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicated in various human diseases like diabetes and cancer. Recent...

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Autores principales:	Yogita Chhichholiya, Aman Kumar Suryan, Prabhat Suman, Anjana Munshi, Sandeep Singh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	miRNA microRNA target genes seed sequences SNPs cancer Genetics QH426-470
Acceso en línea:	https://doaj.org/article/14e17280fec144778a366805258f952e
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spelling	oai:doaj.org-article:14e17280fec144778a366805258f952e2021-12-02T00:14:24ZSNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes1664-802110.3389/fgene.2021.793523https://doaj.org/article/14e17280fec144778a366805258f952e2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.793523/fullhttps://doaj.org/toc/1664-8021miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicated in various human diseases like diabetes and cancer. Recently, geneticists across the world started reporting single nucleotide polymorphism (SNPs) in seed sequences of miRNAs. Similarly, SNPs are also reported in various target sequences of these miRNAs. Both the scenarios lead to dysregulated gene expression which may result in the progression of diseases. In the present paper, we explore SNPs in various miRNAs and their target sequences reported in various human cancers as well as diabetes. Similarly, we also present evidence of these mutations in various other human diseases.Yogita ChhichholiyaAman Kumar SuryanPrabhat SumanAnjana MunshiSandeep SinghFrontiers Media S.A.articlemiRNAmicroRNAtarget genesseed sequencesSNPscancerGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA microRNA target genes seed sequences SNPs cancer Genetics QH426-470
spellingShingle	miRNA microRNA target genes seed sequences SNPs cancer Genetics QH426-470 Yogita Chhichholiya Aman Kumar Suryan Prabhat Suman Anjana Munshi Sandeep Singh SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
description	miRNAs are fascinating molecular players for gene regulation as individual miRNA can control multiple targets and a single target can be regulated by multiple miRNAs. Loss of miRNA regulated gene expression is often reported to be implicated in various human diseases like diabetes and cancer. Recently, geneticists across the world started reporting single nucleotide polymorphism (SNPs) in seed sequences of miRNAs. Similarly, SNPs are also reported in various target sequences of these miRNAs. Both the scenarios lead to dysregulated gene expression which may result in the progression of diseases. In the present paper, we explore SNPs in various miRNAs and their target sequences reported in various human cancers as well as diabetes. Similarly, we also present evidence of these mutations in various other human diseases.
format	article
author	Yogita Chhichholiya Aman Kumar Suryan Prabhat Suman Anjana Munshi Sandeep Singh
author_facet	Yogita Chhichholiya Aman Kumar Suryan Prabhat Suman Anjana Munshi Sandeep Singh
author_sort	Yogita Chhichholiya
title	SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
title_short	SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
title_full	SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
title_fullStr	SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
title_full_unstemmed	SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes
title_sort	snps in mirnas and target sequences: role in cancer and diabetes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/14e17280fec144778a366805258f952e
work_keys_str_mv	AT yogitachhichholiya snpsinmirnasandtargetsequencesroleincanceranddiabetes AT amankumarsuryan snpsinmirnasandtargetsequencesroleincanceranddiabetes AT prabhatsuman snpsinmirnasandtargetsequencesroleincanceranddiabetes AT anjanamunshi snpsinmirnasandtargetsequencesroleincanceranddiabetes AT sandeepsingh snpsinmirnasandtargetsequencesroleincanceranddiabetes
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SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes

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