Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
(1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circu...
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2021
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oai:doaj.org-article:14e1e72a4ed74d6cb48aa46387081c382021-11-25T18:37:00ZClinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years10.3390/nu131141312072-6643https://doaj.org/article/14e1e72a4ed74d6cb48aa46387081c382021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4131https://doaj.org/toc/2072-6643(1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circumstances. We aimed to assess the clinical picture of pediatric CD patients at diagnosis and to validate ESPGHAN non-biopsy criteria. (2) Methods: Patients with suspected CD or undergoing screening from 2004 to 2014 at the University Hospital in Modena, Italy were enrolled. The accuracy of ESPGHAN non-biopsy criteria and modified versions were assessed. (3) Results: In total, 410 patients were enrolled, of whom 403 were considered for analysis. Of the patients considered, 45 were asymptomatic and diagnosed with CD (11.2%) while 358 patients (88.2%) were symptomatic, of whom 295 were diagnosed with CD. Among symptomatic CD patients, 57 (19.3%) had gastrointestinal symptoms, 98 (33%) had atypical symptoms and 140 (47.4%) had both. No difference was found for the presence of gastrointestinal symptoms at different ages. The non-biopsy ESPGHAN criteria yielded an accuracy of 59.4% with a positive predictive value (PPV) of 100%; 173 out of 308 EGD (56.2%) could have been avoided. The modified 7× and 5× upper limit of normal cut-offs for IgA anti tissue-transglutaminase reached 60.7% and 64.3% of EGD avoided, respectively. (4) Conclusions: Over 10 years, late age at diagnosis and increased rates of atypical CD presentation were found. ESPGHAN non-biopsy criteria are accurate for CD diagnosis and allow half of unneeded EGD to be avoided. Modified versions allowed sparing a greater number of EGD.Anna Rita Di BiaseGiovanni MarascoFederico RavaioliLuigi ColecchiaElton DajtiMarco LecisErica PassiniLuigina Vanessa AlemanniDavide FestiLorenzo IughettiAntonio ColecchiaMDPI AGarticleceliac diseaseESPGHANtransglutaminaseesophagogastroduodenoscopypediatric ageNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4131, p 4131 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
celiac disease ESPGHAN transglutaminase esophagogastroduodenoscopy pediatric age Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
celiac disease ESPGHAN transglutaminase esophagogastroduodenoscopy pediatric age Nutrition. Foods and food supply TX341-641 Anna Rita Di Biase Giovanni Marasco Federico Ravaioli Luigi Colecchia Elton Dajti Marco Lecis Erica Passini Luigina Vanessa Alemanni Davide Festi Lorenzo Iughetti Antonio Colecchia Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years |
| description |
(1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circumstances. We aimed to assess the clinical picture of pediatric CD patients at diagnosis and to validate ESPGHAN non-biopsy criteria. (2) Methods: Patients with suspected CD or undergoing screening from 2004 to 2014 at the University Hospital in Modena, Italy were enrolled. The accuracy of ESPGHAN non-biopsy criteria and modified versions were assessed. (3) Results: In total, 410 patients were enrolled, of whom 403 were considered for analysis. Of the patients considered, 45 were asymptomatic and diagnosed with CD (11.2%) while 358 patients (88.2%) were symptomatic, of whom 295 were diagnosed with CD. Among symptomatic CD patients, 57 (19.3%) had gastrointestinal symptoms, 98 (33%) had atypical symptoms and 140 (47.4%) had both. No difference was found for the presence of gastrointestinal symptoms at different ages. The non-biopsy ESPGHAN criteria yielded an accuracy of 59.4% with a positive predictive value (PPV) of 100%; 173 out of 308 EGD (56.2%) could have been avoided. The modified 7× and 5× upper limit of normal cut-offs for IgA anti tissue-transglutaminase reached 60.7% and 64.3% of EGD avoided, respectively. (4) Conclusions: Over 10 years, late age at diagnosis and increased rates of atypical CD presentation were found. ESPGHAN non-biopsy criteria are accurate for CD diagnosis and allow half of unneeded EGD to be avoided. Modified versions allowed sparing a greater number of EGD. |
| format |
article |
| author |
Anna Rita Di Biase Giovanni Marasco Federico Ravaioli Luigi Colecchia Elton Dajti Marco Lecis Erica Passini Luigina Vanessa Alemanni Davide Festi Lorenzo Iughetti Antonio Colecchia |
| author_facet |
Anna Rita Di Biase Giovanni Marasco Federico Ravaioli Luigi Colecchia Elton Dajti Marco Lecis Erica Passini Luigina Vanessa Alemanni Davide Festi Lorenzo Iughetti Antonio Colecchia |
| author_sort |
Anna Rita Di Biase |
| title |
Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years |
| title_short |
Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years |
| title_full |
Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years |
| title_fullStr |
Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years |
| title_full_unstemmed |
Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years |
| title_sort |
clinical presentation of celiac disease and diagnosis accuracy in a single-center european pediatric cohort over 10 years |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/14e1e72a4ed74d6cb48aa46387081c38 |
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