Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little of the mechanism is known. Here the authors show that Sertoli cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy member proteins to clear apoptotic germ cells.

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Autores principales:	Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar, Manjeet K. Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14e208c481df43b3b2eb76f2b8f0b5a9
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spelling	oai:doaj.org-article:14e208c481df43b3b2eb76f2b8f0b5a92021-12-02T14:42:20ZCross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells10.1038/s41467-017-00590-92041-1723https://doaj.org/article/14e208c481df43b3b2eb76f2b8f0b5a92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00590-9https://doaj.org/toc/2041-1723Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little of the mechanism is known. Here the authors show that Sertoli cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy member proteins to clear apoptotic germ cells.Subbarayalu PanneerdossSuryavathi ViswanadhapalliNourhan AbdelfattahBenjamin C. OnyeaguchaSantosh TimilsinaTabrez A. MohammadYidong ChenMichael DrakeKristiina VuoriT. Rajendra KumarManjeet K. RaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Subbarayalu Panneerdoss Suryavathi Viswanadhapalli Nourhan Abdelfattah Benjamin C. Onyeagucha Santosh Timilsina Tabrez A. Mohammad Yidong Chen Michael Drake Kristiina Vuori T. Rajendra Kumar Manjeet K. Rao Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
description	Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little of the mechanism is known. Here the authors show that Sertoli cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy member proteins to clear apoptotic germ cells.
format	article
author	Subbarayalu Panneerdoss Suryavathi Viswanadhapalli Nourhan Abdelfattah Benjamin C. Onyeagucha Santosh Timilsina Tabrez A. Mohammad Yidong Chen Michael Drake Kristiina Vuori T. Rajendra Kumar Manjeet K. Rao
author_facet	Subbarayalu Panneerdoss Suryavathi Viswanadhapalli Nourhan Abdelfattah Benjamin C. Onyeagucha Santosh Timilsina Tabrez A. Mohammad Yidong Chen Michael Drake Kristiina Vuori T. Rajendra Kumar Manjeet K. Rao
author_sort	Subbarayalu Panneerdoss
title	Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
title_short	Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
title_full	Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
title_fullStr	Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
title_full_unstemmed	Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
title_sort	cross-talk between mir-471-5p and autophagy component proteins regulates lc3-associated phagocytosis (lap) of apoptotic germ cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14e208c481df43b3b2eb76f2b8f0b5a9
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Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

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