Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamina...

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Autores principales:	Eduardo Pulgar, Cornelia Schwayer, Néstor Guerrero, Loreto López, Susana Márquez, Steffen Härtel, Rodrigo Soto, Carl-Philipp Heisenberg, Miguel L Concha
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	cell delamination apical constriction dragging mechanical forces collective locomotion dorsal forerunner cells Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/14e379a718f14f0eab4658e1ac491154
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spelling	oai:doaj.org-article:14e379a718f14f0eab4658e1ac4911542021-11-23T17:00:37ZApical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism10.7554/eLife.664832050-084Xe66483https://doaj.org/article/14e379a718f14f0eab4658e1ac4911542021-08-01T00:00:00Zhttps://elifesciences.org/articles/66483https://doaj.org/toc/2050-084XThe developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development.Eduardo PulgarCornelia SchwayerNéstor GuerreroLoreto LópezSusana MárquezSteffen HärtelRodrigo SotoCarl-Philipp HeisenbergMiguel L ConchaeLife Sciences Publications Ltdarticlecell delaminationapical constrictiondraggingmechanical forcescollective locomotiondorsal forerunner cellsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell delamination apical constriction dragging mechanical forces collective locomotion dorsal forerunner cells Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	cell delamination apical constriction dragging mechanical forces collective locomotion dorsal forerunner cells Medicine R Science Q Biology (General) QH301-705.5 Eduardo Pulgar Cornelia Schwayer Néstor Guerrero Loreto López Susana Márquez Steffen Härtel Rodrigo Soto Carl-Philipp Heisenberg Miguel L Concha Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
description	The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development.
format	article
author	Eduardo Pulgar Cornelia Schwayer Néstor Guerrero Loreto López Susana Márquez Steffen Härtel Rodrigo Soto Carl-Philipp Heisenberg Miguel L Concha
author_facet	Eduardo Pulgar Cornelia Schwayer Néstor Guerrero Loreto López Susana Márquez Steffen Härtel Rodrigo Soto Carl-Philipp Heisenberg Miguel L Concha
author_sort	Eduardo Pulgar
title	Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
title_short	Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
title_full	Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
title_fullStr	Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
title_full_unstemmed	Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
title_sort	apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/14e379a718f14f0eab4658e1ac491154
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_version_	1718416196051664896

Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

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