EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA

Abstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in health...

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Autores principales:	V. A. Mikhailova, Y. S. Onokhina, O. M. Ovchinnikova, M. I. Mirashvili, M. S. Zainulina, S. A. Sel’kov, D. I. Sokolov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cd4+т-lymphocytes pregnancy pre-eclampsia cd184 cd47 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/14e511741f9940cc8c76ebe0d3dfb5cd
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spelling	oai:doaj.org-article:14e511741f9940cc8c76ebe0d3dfb5cd2021-11-18T08:03:40ZEXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA1563-06252313-741X10.15789/1563-0625-2012-3-195-200https://doaj.org/article/14e511741f9940cc8c76ebe0d3dfb5cd2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/346https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in healthy pregnancy and in pre-eclampsia. The amounts of CD4+T-lymphocytes expressing CD184, CD119, CD192, CD197, β7 integrin, CD29, CD49d, CD11b were elevated in healthy pregnant women, as compared with non-pregnant women. The amounts of CD4+T-lymphocytes expressing CD49d, CD44, CD47, as well as intensity of CD47, CD29, CD49d, CD44, Integrin β7, CD54 expression proved to be decreased in cases of preeclampsia when compared with healthy pregnancy. This work was supported by grants ГК N 02.740.11.0711 from Russian Ministry of Education and Science, and Presidential grants НШ-3594.2010.7, МД-150.2011.7.V. A. MikhailovaY. S. OnokhinaO. M. OvchinnikovaM. I. MirashviliM. S. ZainulinaS. A. Sel’kovD. I. SokolovSPb RAACIarticlecd4+т-lymphocytespregnancypre-eclampsiacd184cd47Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 3, Pp 195-200 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cd4+т-lymphocytes pregnancy pre-eclampsia cd184 cd47 Immunologic diseases. Allergy RC581-607
spellingShingle	cd4+т-lymphocytes pregnancy pre-eclampsia cd184 cd47 Immunologic diseases. Allergy RC581-607 V. A. Mikhailova Y. S. Onokhina O. M. Ovchinnikova M. I. Mirashvili M. S. Zainulina S. A. Sel’kov D. I. Sokolov EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
description	Abstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in healthy pregnancy and in pre-eclampsia. The amounts of CD4+T-lymphocytes expressing CD184, CD119, CD192, CD197, β7 integrin, CD29, CD49d, CD11b were elevated in healthy pregnant women, as compared with non-pregnant women. The amounts of CD4+T-lymphocytes expressing CD49d, CD44, CD47, as well as intensity of CD47, CD29, CD49d, CD44, Integrin β7, CD54 expression proved to be decreased in cases of preeclampsia when compared with healthy pregnancy. This work was supported by grants ГК N 02.740.11.0711 from Russian Ministry of Education and Science, and Presidential grants НШ-3594.2010.7, МД-150.2011.7.
format	article
author	V. A. Mikhailova Y. S. Onokhina O. M. Ovchinnikova M. I. Mirashvili M. S. Zainulina S. A. Sel’kov D. I. Sokolov
author_facet	V. A. Mikhailova Y. S. Onokhina O. M. Ovchinnikova M. I. Mirashvili M. S. Zainulina S. A. Sel’kov D. I. Sokolov
author_sort	V. A. Mikhailova
title	EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
title_short	EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
title_full	EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
title_fullStr	EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
title_full_unstemmed	EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
title_sort	expression of surface markers on cd4+t-lymphocytes in normal pregnancy and pre-eclampsia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/14e511741f9940cc8c76ebe0d3dfb5cd
work_keys_str_mv	AT vamikhailova expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia AT ysonokhina expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia AT omovchinnikova expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia AT mimirashvili expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia AT mszainulina expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia AT saselkov expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia AT disokolov expressionofsurfacemarkersoncd4tlymphocytesinnormalpregnancyandpreeclampsia
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EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA

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