Factors related to hypertensive phase after glaucoma drainage device implantation

Orathai Pitukcheewanont,1 Visanee Tantisevi,1 Sunee Chansangpetch,2 Prin Rojanapongpun1 1Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand Back...

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Autores principales:	Pitukcheewanont O, Tantisevi V, Chansangpetch S, Rojanapongpun P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Glaucoma implant post-operative intra-ocular pressure risk factors surgical outcomes Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/14e8fa546a2f4bdea687031f9b837b96
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spelling	oai:doaj.org-article:14e8fa546a2f4bdea687031f9b837b962021-12-02T09:05:54ZFactors related to hypertensive phase after glaucoma drainage device implantation1177-5483https://doaj.org/article/14e8fa546a2f4bdea687031f9b837b962018-08-01T00:00:00Zhttps://www.dovepress.com/factors-related-to-hypertensive-phase-after-glaucoma-drainage-device-i-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Orathai Pitukcheewanont,1 Visanee Tantisevi,1 Sunee Chansangpetch,2 Prin Rojanapongpun1 1Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand Background: The aim of the study was to evaluate factors related to hypertensive phase (HP) after glaucoma drainage device (GDD) implantation.Patients and methods: Retrospective charts review of glaucoma patients who underwent GDD implantation and completed 12 months of follow-up at King Chulalongkorn Memorial Hospital since 2004 was performed. Patients were divided into two groups according to the presence or absence of HP. The data were analyzed for factors associated with HP. The surgical outcomes including surgical failure, post-operative visual acuity (VA), post-operative number of medications, post-operative intraocular pressure (IOP), and post-operative complication were compared between the two groups.Results: Seventy-two patients were included. Most were diagnosed with secondary glaucoma (N=51, 70.8%), and Baerveldt was the most implanted GDD (N=49, 68.1%). Mean ± SD of IOP was significantly lower: 27.1±9.6 mmHg at pre-operation and 13.7±59 mmHg at 12-month follow-up (p<0.001). HP was identified in 38/72 patients (52.8%, 95% CI 40.7–64.7). Risk factor of HP was pre-operative VA equal or better than 20/70 (p=0.021, OR 7.5; 95% CI 1.4–41.4). Presence of underlying heart disease (patients in this group had taken anti-platelets) was found as a protective factor for HP (p=0.027, OR 0.06; 95% CI 0.00–0.72). It was speculated that the anti-inflammatory effect of the anti-platelets, particularly aspirin, may be responsible for controlling inflammation and retarding fibrosis formation around drainage implants. Failure rate at 12 months was 24/72 (33%). There was no difference in all surgical outcomes between the two groups. Survival analysis also showed no significant difference between HP and non-HP group.Conclusion: HP commonly occurred after GDD implantation. Pre-operative VA was a risk factor for the development of HP, whereas presence of underlying heart disease was a protective factor. No association between HP and surgical outcomes was identified. Keywords: glaucoma implant, post-operative intraocular pressure, risk factors, surgical outcomesPitukcheewanont OTantisevi VChansangpetch SRojanapongpun PDove Medical PressarticleGlaucoma implantpost-operative intra-ocular pressurerisk factorssurgical outcomesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1479-1486 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glaucoma implant post-operative intra-ocular pressure risk factors surgical outcomes Ophthalmology RE1-994
spellingShingle	Glaucoma implant post-operative intra-ocular pressure risk factors surgical outcomes Ophthalmology RE1-994 Pitukcheewanont O Tantisevi V Chansangpetch S Rojanapongpun P Factors related to hypertensive phase after glaucoma drainage device implantation
description	Orathai Pitukcheewanont,1 Visanee Tantisevi,1 Sunee Chansangpetch,2 Prin Rojanapongpun1 1Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand Background: The aim of the study was to evaluate factors related to hypertensive phase (HP) after glaucoma drainage device (GDD) implantation.Patients and methods: Retrospective charts review of glaucoma patients who underwent GDD implantation and completed 12 months of follow-up at King Chulalongkorn Memorial Hospital since 2004 was performed. Patients were divided into two groups according to the presence or absence of HP. The data were analyzed for factors associated with HP. The surgical outcomes including surgical failure, post-operative visual acuity (VA), post-operative number of medications, post-operative intraocular pressure (IOP), and post-operative complication were compared between the two groups.Results: Seventy-two patients were included. Most were diagnosed with secondary glaucoma (N=51, 70.8%), and Baerveldt was the most implanted GDD (N=49, 68.1%). Mean ± SD of IOP was significantly lower: 27.1±9.6 mmHg at pre-operation and 13.7±59 mmHg at 12-month follow-up (p<0.001). HP was identified in 38/72 patients (52.8%, 95% CI 40.7–64.7). Risk factor of HP was pre-operative VA equal or better than 20/70 (p=0.021, OR 7.5; 95% CI 1.4–41.4). Presence of underlying heart disease (patients in this group had taken anti-platelets) was found as a protective factor for HP (p=0.027, OR 0.06; 95% CI 0.00–0.72). It was speculated that the anti-inflammatory effect of the anti-platelets, particularly aspirin, may be responsible for controlling inflammation and retarding fibrosis formation around drainage implants. Failure rate at 12 months was 24/72 (33%). There was no difference in all surgical outcomes between the two groups. Survival analysis also showed no significant difference between HP and non-HP group.Conclusion: HP commonly occurred after GDD implantation. Pre-operative VA was a risk factor for the development of HP, whereas presence of underlying heart disease was a protective factor. No association between HP and surgical outcomes was identified. Keywords: glaucoma implant, post-operative intraocular pressure, risk factors, surgical outcomes
format	article
author	Pitukcheewanont O Tantisevi V Chansangpetch S Rojanapongpun P
author_facet	Pitukcheewanont O Tantisevi V Chansangpetch S Rojanapongpun P
author_sort	Pitukcheewanont O
title	Factors related to hypertensive phase after glaucoma drainage device implantation
title_short	Factors related to hypertensive phase after glaucoma drainage device implantation
title_full	Factors related to hypertensive phase after glaucoma drainage device implantation
title_fullStr	Factors related to hypertensive phase after glaucoma drainage device implantation
title_full_unstemmed	Factors related to hypertensive phase after glaucoma drainage device implantation
title_sort	factors related to hypertensive phase after glaucoma drainage device implantation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/14e8fa546a2f4bdea687031f9b837b96
work_keys_str_mv	AT pitukcheewanonto factorsrelatedtohypertensivephaseafterglaucomadrainagedeviceimplantation AT tantiseviv factorsrelatedtohypertensivephaseafterglaucomadrainagedeviceimplantation AT chansangpetchs factorsrelatedtohypertensivephaseafterglaucomadrainagedeviceimplantation AT rojanapongpunp factorsrelatedtohypertensivephaseafterglaucomadrainagedeviceimplantation
_version_	1718398226028036096

Factors related to hypertensive phase after glaucoma drainage device implantation

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