m5C modification of mRNA serves a DNA damage code to promote homologous recombination

m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

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Detalles Bibliográficos
Autores principales: Hao Chen, Haibo Yang, Xiaolan Zhu, Tribhuwan Yadav, Jian Ouyang, Samuel S. Truesdell, Jun Tan, Yumin Wang, Meihan Duan, Leizhen Wei, Lee Zou, Arthur S. Levine, Shobha Vasudevan, Li Lan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/14e92aba6993424088f192e1fc7c093c
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Descripción
Sumario:Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

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