m5C modification of mRNA serves a DNA damage code to promote homologous recombination

Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.

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Autores principales:	Hao Chen, Haibo Yang, Xiaolan Zhu, Tribhuwan Yadav, Jian Ouyang, Samuel S. Truesdell, Jun Tan, Yumin Wang, Meihan Duan, Leizhen Wei, Lee Zou, Arthur S. Levine, Shobha Vasudevan, Li Lan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14e92aba6993424088f192e1fc7c093c
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spelling	oai:doaj.org-article:14e92aba6993424088f192e1fc7c093c2021-12-02T18:24:58Zm5C modification of mRNA serves a DNA damage code to promote homologous recombination10.1038/s41467-020-16722-72041-1723https://doaj.org/article/14e92aba6993424088f192e1fc7c093c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16722-7https://doaj.org/toc/2041-1723Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.Hao ChenHaibo YangXiaolan ZhuTribhuwan YadavJian OuyangSamuel S. TruesdellJun TanYumin WangMeihan DuanLeizhen WeiLee ZouArthur S. LevineShobha VasudevanLi LanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Chen Haibo Yang Xiaolan Zhu Tribhuwan Yadav Jian Ouyang Samuel S. Truesdell Jun Tan Yumin Wang Meihan Duan Leizhen Wei Lee Zou Arthur S. Levine Shobha Vasudevan Li Lan m5C modification of mRNA serves a DNA damage code to promote homologous recombination
description	Post-translational modifications of proteins at DNA damage sites can facilitate the recruitment of DNA repair factors. Here, the authors show that mRNA is locally modified with m5C at sites of DNA damage by the RNA methyltransferase TRDMT1 to promote homologous recombination repair.
format	article
author	Hao Chen Haibo Yang Xiaolan Zhu Tribhuwan Yadav Jian Ouyang Samuel S. Truesdell Jun Tan Yumin Wang Meihan Duan Leizhen Wei Lee Zou Arthur S. Levine Shobha Vasudevan Li Lan
author_facet	Hao Chen Haibo Yang Xiaolan Zhu Tribhuwan Yadav Jian Ouyang Samuel S. Truesdell Jun Tan Yumin Wang Meihan Duan Leizhen Wei Lee Zou Arthur S. Levine Shobha Vasudevan Li Lan
author_sort	Hao Chen
title	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_short	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_full	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_fullStr	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_full_unstemmed	m5C modification of mRNA serves a DNA damage code to promote homologous recombination
title_sort	m5c modification of mrna serves a dna damage code to promote homologous recombination
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/14e92aba6993424088f192e1fc7c093c
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m5C modification of mRNA serves a DNA damage code to promote homologous recombination

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