The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
Abstract Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment...
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Nature Portfolio
2021
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oai:doaj.org-article:14e9b5ecda134393bd94a0a2a36385cd2021-12-02T14:12:08ZThe effects of meldonium on the acute ischemia/reperfusion liver injury in rats10.1038/s41598-020-80011-y2045-2322https://doaj.org/article/14e9b5ecda134393bd94a0a2a36385cd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80011-yhttps://doaj.org/toc/2045-2322Abstract Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.Siniša ĐuraševićMaja StojkovićJelena SoptaSlađan PavlovićSlavica Borković-MitićAnđelija IvanovićNebojša JasnićTomislav TostiSaša ĐurovićJelena ĐorđevićZoran TodorovićNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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Medicine R Science Q Siniša Đurašević Maja Stojković Jelena Sopta Slađan Pavlović Slavica Borković-Mitić Anđelija Ivanović Nebojša Jasnić Tomislav Tosti Saša Đurović Jelena Đorđević Zoran Todorović The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
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Abstract Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. |
| format |
article |
| author |
Siniša Đurašević Maja Stojković Jelena Sopta Slađan Pavlović Slavica Borković-Mitić Anđelija Ivanović Nebojša Jasnić Tomislav Tosti Saša Đurović Jelena Đorđević Zoran Todorović |
| author_facet |
Siniša Đurašević Maja Stojković Jelena Sopta Slađan Pavlović Slavica Borković-Mitić Anđelija Ivanović Nebojša Jasnić Tomislav Tosti Saša Đurović Jelena Đorđević Zoran Todorović |
| author_sort |
Siniša Đurašević |
| title |
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
| title_short |
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
| title_full |
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
| title_fullStr |
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
| title_full_unstemmed |
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
| title_sort |
effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/14e9b5ecda134393bd94a0a2a36385cd |
| work_keys_str_mv |
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