Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz deficiency in the cerebellum.
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Nature Portfolio
2020
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oai:doaj.org-article:14ea55860cc94204933e8e502705deac2021-12-02T14:40:27ZPogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice10.1038/s41467-020-19577-02041-1723https://doaj.org/article/14ea55860cc94204933e8e502705deac2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19577-0https://doaj.org/toc/2041-1723POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz deficiency in the cerebellum.Reut Suliman-LavieBen TitleYahel CohenNanako HamadaMaayan TalNitzan TalGalya Monderer-RothkoffBjorg GudmundsdottirKristbjorn O. GudmundssonJonathan R. KellerGuo-Jen HuangKoh-ichi NagataYosef YaromSagiv ShifmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Reut Suliman-Lavie Ben Title Yahel Cohen Nanako Hamada Maayan Tal Nitzan Tal Galya Monderer-Rothkoff Bjorg Gudmundsdottir Kristbjorn O. Gudmundsson Jonathan R. Keller Guo-Jen Huang Koh-ichi Nagata Yosef Yarom Sagiv Shifman Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| description |
POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz deficiency in the cerebellum. |
| format |
article |
| author |
Reut Suliman-Lavie Ben Title Yahel Cohen Nanako Hamada Maayan Tal Nitzan Tal Galya Monderer-Rothkoff Bjorg Gudmundsdottir Kristbjorn O. Gudmundsson Jonathan R. Keller Guo-Jen Huang Koh-ichi Nagata Yosef Yarom Sagiv Shifman |
| author_facet |
Reut Suliman-Lavie Ben Title Yahel Cohen Nanako Hamada Maayan Tal Nitzan Tal Galya Monderer-Rothkoff Bjorg Gudmundsdottir Kristbjorn O. Gudmundsson Jonathan R. Keller Guo-Jen Huang Koh-ichi Nagata Yosef Yarom Sagiv Shifman |
| author_sort |
Reut Suliman-Lavie |
| title |
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| title_short |
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| title_full |
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| title_fullStr |
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| title_full_unstemmed |
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| title_sort |
pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/14ea55860cc94204933e8e502705deac |
| work_keys_str_mv |
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