Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents formation of adhesions in mice.

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Autores principales:	Adrian Fischer, Tim Koopmans, Pushkar Ramesh, Simon Christ, Maximilian Strunz, Juliane Wannemacher, Michaela Aichler, Annette Feuchtinger, Axel Walch, Meshal Ansari, Fabian J. Theis, Kenji Schorpp, Kamyar Hadian, Philipp-Alexander Neumann, Herbert B. Schiller, Yuval Rinkevich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14eab87dfd66492c8aa804c34480c9bf
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spelling	oai:doaj.org-article:14eab87dfd66492c8aa804c34480c9bf2021-12-02T17:23:48ZPost-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces10.1038/s41467-020-16893-32041-1723https://doaj.org/article/14eab87dfd66492c8aa804c34480c9bf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16893-3https://doaj.org/toc/2041-1723Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents formation of adhesions in mice.Adrian FischerTim KoopmansPushkar RameshSimon ChristMaximilian StrunzJuliane WannemacherMichaela AichlerAnnette FeuchtingerAxel WalchMeshal AnsariFabian J. TheisKenji SchorppKamyar HadianPhilipp-Alexander NeumannHerbert B. SchillerYuval RinkevichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adrian Fischer Tim Koopmans Pushkar Ramesh Simon Christ Maximilian Strunz Juliane Wannemacher Michaela Aichler Annette Feuchtinger Axel Walch Meshal Ansari Fabian J. Theis Kenji Schorpp Kamyar Hadian Philipp-Alexander Neumann Herbert B. Schiller Yuval Rinkevich Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
description	Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents formation of adhesions in mice.
format	article
author	Adrian Fischer Tim Koopmans Pushkar Ramesh Simon Christ Maximilian Strunz Juliane Wannemacher Michaela Aichler Annette Feuchtinger Axel Walch Meshal Ansari Fabian J. Theis Kenji Schorpp Kamyar Hadian Philipp-Alexander Neumann Herbert B. Schiller Yuval Rinkevich
author_facet	Adrian Fischer Tim Koopmans Pushkar Ramesh Simon Christ Maximilian Strunz Juliane Wannemacher Michaela Aichler Annette Feuchtinger Axel Walch Meshal Ansari Fabian J. Theis Kenji Schorpp Kamyar Hadian Philipp-Alexander Neumann Herbert B. Schiller Yuval Rinkevich
author_sort	Adrian Fischer
title	Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
title_short	Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
title_full	Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
title_fullStr	Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
title_full_unstemmed	Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
title_sort	post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/14eab87dfd66492c8aa804c34480c9bf
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Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

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