Periorbital muscle atrophy associated with topical bimatoprost therapy

Priscilla Xinhui Wang, Victor Teck Chang Koh, Jin Fong ChengDepartment of Ophthalmology, National University Health System, SingaporeAbstract: Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocul...

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Autores principales:	Wang PX, Koh VT, Cheng JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/14eac15c4d014f6d844f547c0c2375fd
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spelling	oai:doaj.org-article:14eac15c4d014f6d844f547c0c2375fd2021-12-02T08:47:13ZPeriorbital muscle atrophy associated with topical bimatoprost therapy1177-5483https://doaj.org/article/14eac15c4d014f6d844f547c0c2375fd2014-01-01T00:00:00Zhttp://www.dovepress.com/periorbital-muscle-atrophy-associated-with-topical-bimatoprost-therapy-a15645https://doaj.org/toc/1177-5483 Priscilla Xinhui Wang, Victor Teck Chang Koh, Jin Fong ChengDepartment of Ophthalmology, National University Health System, SingaporeAbstract: Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocular hyperaemia, ocular pruritus, and periocular and iris pigmentary changes. Perioribital lipodystrophy is another well-documented outcome associated with chronic use of topical bimatoprost, which results in periorbital hallowing, upper eyelid sulcus deepening, eyelid retraction and enophthalmos. We report an unusual case of periocular muscle atrophy and weakness from unilateral topical bimatoprost use. Our patient had primary angle closure and experienced a right upper eyelid ptosis 2 months after she started to use topical bimatoprost in that eye. Clinical measurements of her eyelids clearly showed reduction in the function of her right levator muscle, suggesting that effects of topical bimatoprost may not be limited to periorbital fat. She was advised to stop topical bimatoprost and right ptosis correction surgery with levator muscle advancement was performed successfully. Ophthalmologists and patients should be aware of this potential rare side effect of topical bimatoprost, as it may be potentially disfiguring, especially with monocular use. However, its exact mechanism of action needs to be clarified further.Keywords: prostaglandin analog, levator, muscle atrophy, muscle weakness, ptosis, side effectsWang PXKoh VTCheng JFDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 311-314 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Wang PX Koh VT Cheng JF Periorbital muscle atrophy associated with topical bimatoprost therapy
description	Priscilla Xinhui Wang, Victor Teck Chang Koh, Jin Fong ChengDepartment of Ophthalmology, National University Health System, SingaporeAbstract: Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocular hyperaemia, ocular pruritus, and periocular and iris pigmentary changes. Perioribital lipodystrophy is another well-documented outcome associated with chronic use of topical bimatoprost, which results in periorbital hallowing, upper eyelid sulcus deepening, eyelid retraction and enophthalmos. We report an unusual case of periocular muscle atrophy and weakness from unilateral topical bimatoprost use. Our patient had primary angle closure and experienced a right upper eyelid ptosis 2 months after she started to use topical bimatoprost in that eye. Clinical measurements of her eyelids clearly showed reduction in the function of her right levator muscle, suggesting that effects of topical bimatoprost may not be limited to periorbital fat. She was advised to stop topical bimatoprost and right ptosis correction surgery with levator muscle advancement was performed successfully. Ophthalmologists and patients should be aware of this potential rare side effect of topical bimatoprost, as it may be potentially disfiguring, especially with monocular use. However, its exact mechanism of action needs to be clarified further.Keywords: prostaglandin analog, levator, muscle atrophy, muscle weakness, ptosis, side effects
format	article
author	Wang PX Koh VT Cheng JF
author_facet	Wang PX Koh VT Cheng JF
author_sort	Wang PX
title	Periorbital muscle atrophy associated with topical bimatoprost therapy
title_short	Periorbital muscle atrophy associated with topical bimatoprost therapy
title_full	Periorbital muscle atrophy associated with topical bimatoprost therapy
title_fullStr	Periorbital muscle atrophy associated with topical bimatoprost therapy
title_full_unstemmed	Periorbital muscle atrophy associated with topical bimatoprost therapy
title_sort	periorbital muscle atrophy associated with topical bimatoprost therapy
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/14eac15c4d014f6d844f547c0c2375fd
work_keys_str_mv	AT wangpx periorbitalmuscleatrophyassociatedwithtopicalbimatoprosttherapy AT kohvt periorbitalmuscleatrophyassociatedwithtopicalbimatoprosttherapy AT chengjf periorbitalmuscleatrophyassociatedwithtopicalbimatoprosttherapy
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Periorbital muscle atrophy associated with topical bimatoprost therapy

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