MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Exercise has beneficial effects on metabolism and overall physiologic fitness in aged organisms. Here the authors show that MOTS-c is a mitochondrial-encoded exercise-induced peptide that regulates skeletal muscle metabolism and improves healthspan of older mice.

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Autores principales:	Joseph C. Reynolds, Rochelle W. Lai, Jonathan S. T. Woodhead, James H. Joly, Cameron J. Mitchell, David Cameron-Smith, Ryan Lu, Pinchas Cohen, Nicholas A. Graham, Bérénice A. Benayoun, Troy L. Merry, Changhan Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14ed889ddbd64ff7a4d462092a15bb16
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spelling	oai:doaj.org-article:14ed889ddbd64ff7a4d462092a15bb162021-12-02T13:57:04ZMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis10.1038/s41467-020-20790-02041-1723https://doaj.org/article/14ed889ddbd64ff7a4d462092a15bb162021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20790-0https://doaj.org/toc/2041-1723Exercise has beneficial effects on metabolism and overall physiologic fitness in aged organisms. Here the authors show that MOTS-c is a mitochondrial-encoded exercise-induced peptide that regulates skeletal muscle metabolism and improves healthspan of older mice.Joseph C. ReynoldsRochelle W. LaiJonathan S. T. WoodheadJames H. JolyCameron J. MitchellDavid Cameron-SmithRyan LuPinchas CohenNicholas A. GrahamBérénice A. BenayounTroy L. MerryChanghan LeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph C. Reynolds Rochelle W. Lai Jonathan S. T. Woodhead James H. Joly Cameron J. Mitchell David Cameron-Smith Ryan Lu Pinchas Cohen Nicholas A. Graham Bérénice A. Benayoun Troy L. Merry Changhan Lee MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
description	Exercise has beneficial effects on metabolism and overall physiologic fitness in aged organisms. Here the authors show that MOTS-c is a mitochondrial-encoded exercise-induced peptide that regulates skeletal muscle metabolism and improves healthspan of older mice.
format	article
author	Joseph C. Reynolds Rochelle W. Lai Jonathan S. T. Woodhead James H. Joly Cameron J. Mitchell David Cameron-Smith Ryan Lu Pinchas Cohen Nicholas A. Graham Bérénice A. Benayoun Troy L. Merry Changhan Lee
author_facet	Joseph C. Reynolds Rochelle W. Lai Jonathan S. T. Woodhead James H. Joly Cameron J. Mitchell David Cameron-Smith Ryan Lu Pinchas Cohen Nicholas A. Graham Bérénice A. Benayoun Troy L. Merry Changhan Lee
author_sort	Joseph C. Reynolds
title	MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
title_short	MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
title_full	MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
title_fullStr	MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
title_full_unstemmed	MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
title_sort	mots-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14ed889ddbd64ff7a4d462092a15bb16
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MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

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