Targeting Selectins Mediated Biological Activities With Multivalent Probes

Selectins are type-I transmembrane glycoproteins that are ubiquitously expressed on activated platelets, endothelial cells, and leukocytes. They bind to cell surface glycoproteins and extracellular matrix ligands, regulate the rolling of leukocytes in the blood capillaries, and recruit them to infla...

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Autores principales:	Deepak Ganesh, Prashant Jain, Chethan Devanur Shanthamurthy, Suraj Toraskar, Raghavendra Kikkeri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	selectins cancer nanoparticles imaging drug delivery Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/14f1119d86cf47588fa2d820a32bb592
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spelling	oai:doaj.org-article:14f1119d86cf47588fa2d820a32bb5922021-12-03T04:37:41ZTargeting Selectins Mediated Biological Activities With Multivalent Probes2296-264610.3389/fchem.2021.773027https://doaj.org/article/14f1119d86cf47588fa2d820a32bb5922021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.773027/fullhttps://doaj.org/toc/2296-2646Selectins are type-I transmembrane glycoproteins that are ubiquitously expressed on activated platelets, endothelial cells, and leukocytes. They bind to cell surface glycoproteins and extracellular matrix ligands, regulate the rolling of leukocytes in the blood capillaries, and recruit them to inflammatory sites. Hence, they are potential markers for the early detection and inhibition of inflammatory diseases, thrombosis, cardiovascular disorders, and tumor metastasis. Fucosylated and sialylated glycans, such as sialyl Lewisx, its isoform sialyl Lewisa, and heparan sulfate, are primary selectin ligands. Functionalization of these selectin-binding ligands on multivalent probes, such as nanoparticles, liposomes, and polymers, not only inhibits selectin-mediated biological activity but is also involved in direct imaging of the inflammation site. This review briefly summarizes the selectin-mediated various diseases such as thrombosis, cancer and recent progress in the different types of multivalent probes used to target selectins.Deepak GaneshPrashant JainChethan Devanur ShanthamurthySuraj ToraskarRaghavendra KikkeriFrontiers Media S.A.articleselectinscancernanoparticlesimagingdrug deliveryChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	selectins cancer nanoparticles imaging drug delivery Chemistry QD1-999
spellingShingle	selectins cancer nanoparticles imaging drug delivery Chemistry QD1-999 Deepak Ganesh Prashant Jain Chethan Devanur Shanthamurthy Suraj Toraskar Raghavendra Kikkeri Targeting Selectins Mediated Biological Activities With Multivalent Probes
description	Selectins are type-I transmembrane glycoproteins that are ubiquitously expressed on activated platelets, endothelial cells, and leukocytes. They bind to cell surface glycoproteins and extracellular matrix ligands, regulate the rolling of leukocytes in the blood capillaries, and recruit them to inflammatory sites. Hence, they are potential markers for the early detection and inhibition of inflammatory diseases, thrombosis, cardiovascular disorders, and tumor metastasis. Fucosylated and sialylated glycans, such as sialyl Lewisx, its isoform sialyl Lewisa, and heparan sulfate, are primary selectin ligands. Functionalization of these selectin-binding ligands on multivalent probes, such as nanoparticles, liposomes, and polymers, not only inhibits selectin-mediated biological activity but is also involved in direct imaging of the inflammation site. This review briefly summarizes the selectin-mediated various diseases such as thrombosis, cancer and recent progress in the different types of multivalent probes used to target selectins.
format	article
author	Deepak Ganesh Prashant Jain Chethan Devanur Shanthamurthy Suraj Toraskar Raghavendra Kikkeri
author_facet	Deepak Ganesh Prashant Jain Chethan Devanur Shanthamurthy Suraj Toraskar Raghavendra Kikkeri
author_sort	Deepak Ganesh
title	Targeting Selectins Mediated Biological Activities With Multivalent Probes
title_short	Targeting Selectins Mediated Biological Activities With Multivalent Probes
title_full	Targeting Selectins Mediated Biological Activities With Multivalent Probes
title_fullStr	Targeting Selectins Mediated Biological Activities With Multivalent Probes
title_full_unstemmed	Targeting Selectins Mediated Biological Activities With Multivalent Probes
title_sort	targeting selectins mediated biological activities with multivalent probes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/14f1119d86cf47588fa2d820a32bb592
work_keys_str_mv	AT deepakganesh targetingselectinsmediatedbiologicalactivitieswithmultivalentprobes AT prashantjain targetingselectinsmediatedbiologicalactivitieswithmultivalentprobes AT chethandevanurshanthamurthy targetingselectinsmediatedbiologicalactivitieswithmultivalentprobes AT surajtoraskar targetingselectinsmediatedbiologicalactivitieswithmultivalentprobes AT raghavendrakikkeri targetingselectinsmediatedbiologicalactivitieswithmultivalentprobes
_version_	1718373914743144448

Targeting Selectins Mediated Biological Activities With Multivalent Probes

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