Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients

Objectives: Procalcitonin (PCT) has long been proved as an early diagnostic signal for postoperative outcomes. The purpose of this study is to explore the value of serum procalcitonin levels in predicting post-hepatectomy liver failure (PHLF), and further to declarethe relationship between postopera...

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Autores principales:	Yi-Ran Li, Xiao-Yan Meng, Rui-Qing Zong, Fei-Xiang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	procalcitonin post-hepatectomy liver failure hepatocellular carcinoma biomarker mortality Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/14f128374ac64386b2252d0cda65530b
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spelling	oai:doaj.org-article:14f128374ac64386b2252d0cda65530b2021-11-18T09:52:01ZAssociation Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients1663-981210.3389/fphar.2021.791322https://doaj.org/article/14f128374ac64386b2252d0cda65530b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.791322/fullhttps://doaj.org/toc/1663-9812Objectives: Procalcitonin (PCT) has long been proved as an early diagnostic signal for postoperative outcomes. The purpose of this study is to explore the value of serum procalcitonin levels in predicting post-hepatectomy liver failure (PHLF), and further to declarethe relationship between postoperative PCT and short-term prognosis in patients after hepatectomy.Methods: Clinical data of patients with hepatocellular carcinoma (HCC) who underwent hepatectomy from June 1st, 2019 to September 31st, 2020 at Shanghai Eastern Hepatobiliary Surgery Hospital had been retrospectively analyzed. Logistic regression analysis was used to evaluate the risk factors related to PHLF. The Kaplan-Meier method was used to calculate the PHLF rate and 30-day survival after surgery.Results: A total of 885 patients with complete data were finally included in analysis, 311 of them with elevated serum PCT (≥1 ng/ml). Results of the logistic regression analysis suggested a significant association between PCT and PHLF [HR, 95%CI; 3.801 (1.825, 7.917), p < 0.001]. Other significant risk factors for PHLF included portal hypertension, portal blocking time (>30 min) and blood transfusion (>200 ml). Kaplan-Meier analysis also suggested a higher PHLF rate in elevated PCT patients [9.0% (95% CI, 7.3 to 12.8 VS. 1.9% (95% CI, 1.1–4.3)); p < 0.001]. For secondary outcomes, elevated PCT was also highly associated with postoperative sepsis, ICU admission, 30-day mortality and 3-month mortality.Conclusion: Elevated procalcitonin level in patients after hepatectomy is related to higher PHLF rate, with lower 30-day survival and poor short-term postoperative outcomes.Yi-Ran LiXiao-Yan MengRui-Qing ZongFei-Xiang WuFrontiers Media S.A.articleprocalcitoninpost-hepatectomy liver failurehepatocellular carcinomabiomarkermortalityTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	procalcitonin post-hepatectomy liver failure hepatocellular carcinoma biomarker mortality Therapeutics. Pharmacology RM1-950
spellingShingle	procalcitonin post-hepatectomy liver failure hepatocellular carcinoma biomarker mortality Therapeutics. Pharmacology RM1-950 Yi-Ran Li Xiao-Yan Meng Rui-Qing Zong Fei-Xiang Wu Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients
description	Objectives: Procalcitonin (PCT) has long been proved as an early diagnostic signal for postoperative outcomes. The purpose of this study is to explore the value of serum procalcitonin levels in predicting post-hepatectomy liver failure (PHLF), and further to declarethe relationship between postoperative PCT and short-term prognosis in patients after hepatectomy.Methods: Clinical data of patients with hepatocellular carcinoma (HCC) who underwent hepatectomy from June 1st, 2019 to September 31st, 2020 at Shanghai Eastern Hepatobiliary Surgery Hospital had been retrospectively analyzed. Logistic regression analysis was used to evaluate the risk factors related to PHLF. The Kaplan-Meier method was used to calculate the PHLF rate and 30-day survival after surgery.Results: A total of 885 patients with complete data were finally included in analysis, 311 of them with elevated serum PCT (≥1 ng/ml). Results of the logistic regression analysis suggested a significant association between PCT and PHLF [HR, 95%CI; 3.801 (1.825, 7.917), p < 0.001]. Other significant risk factors for PHLF included portal hypertension, portal blocking time (>30 min) and blood transfusion (>200 ml). Kaplan-Meier analysis also suggested a higher PHLF rate in elevated PCT patients [9.0% (95% CI, 7.3 to 12.8 VS. 1.9% (95% CI, 1.1–4.3)); p < 0.001]. For secondary outcomes, elevated PCT was also highly associated with postoperative sepsis, ICU admission, 30-day mortality and 3-month mortality.Conclusion: Elevated procalcitonin level in patients after hepatectomy is related to higher PHLF rate, with lower 30-day survival and poor short-term postoperative outcomes.
format	article
author	Yi-Ran Li Xiao-Yan Meng Rui-Qing Zong Fei-Xiang Wu
author_facet	Yi-Ran Li Xiao-Yan Meng Rui-Qing Zong Fei-Xiang Wu
author_sort	Yi-Ran Li
title	Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients
title_short	Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients
title_full	Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients
title_fullStr	Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients
title_full_unstemmed	Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients
title_sort	association between procalcitonin and post-hepatectomy liver failure in hepatocellular carcinoma patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/14f128374ac64386b2252d0cda65530b
work_keys_str_mv	AT yiranli associationbetweenprocalcitoninandposthepatectomyliverfailureinhepatocellularcarcinomapatients AT xiaoyanmeng associationbetweenprocalcitoninandposthepatectomyliverfailureinhepatocellularcarcinomapatients AT ruiqingzong associationbetweenprocalcitoninandposthepatectomyliverfailureinhepatocellularcarcinomapatients AT feixiangwu associationbetweenprocalcitoninandposthepatectomyliverfailureinhepatocellularcarcinomapatients
_version_	1718420829366124544

Association Between Procalcitonin and Post-hepatectomy Liver Failure in Hepatocellular Carcinoma Patients

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