FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce elevated levels of activity in Fmr1 KO mice.

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Autores principales:	Xiaoqin Zhan, Hadhimulya Asmara, Ning Cheng, Giriraj Sahu, Eduardo Sanchez, Fang-Xiong Zhang, Gerald W. Zamponi, Jong M. Rho, Ray W. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c
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spelling	oai:doaj.org-article:14f1b5ef2d044bbe97bc456fbccfe24c2021-12-02T15:02:47ZFMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome10.1038/s41467-020-16250-42041-1723https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16250-4https://doaj.org/toc/2041-1723Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce elevated levels of activity in Fmr1 KO mice.Xiaoqin ZhanHadhimulya AsmaraNing ChengGiriraj SahuEduardo SanchezFang-Xiong ZhangGerald W. ZamponiJong M. RhoRay W. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoqin Zhan Hadhimulya Asmara Ning Cheng Giriraj Sahu Eduardo Sanchez Fang-Xiong Zhang Gerald W. Zamponi Jong M. Rho Ray W. Turner FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
description	Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce elevated levels of activity in Fmr1 KO mice.
format	article
author	Xiaoqin Zhan Hadhimulya Asmara Ning Cheng Giriraj Sahu Eduardo Sanchez Fang-Xiong Zhang Gerald W. Zamponi Jong M. Rho Ray W. Turner
author_facet	Xiaoqin Zhan Hadhimulya Asmara Ning Cheng Giriraj Sahu Eduardo Sanchez Fang-Xiong Zhang Gerald W. Zamponi Jong M. Rho Ray W. Turner
author_sort	Xiaoqin Zhan
title	FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
title_short	FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
title_full	FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
title_fullStr	FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
title_full_unstemmed	FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
title_sort	fmrp(1–297)-tat restores ion channel and synaptic function in a model of fragile x syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c
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FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

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