Meta-analysis of host response networks identifies a common core in tuberculosis

Tuberculosis: an underlying common-core host response network Patients suffering from tuberculosis (TB) show a high extent of variations in their gene expression patterns. Such heterogeneity poses major road blocks to our understanding of how hosts respond to the disease. A number of studies have pr...

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Autores principales:	Awanti Sambarey, Abhinandan Devaprasad, Priyanka Baloni, Madhulika Mishra, Abhilash Mohan, Priyanka Tyagi, Amit Singh, JS Akshata, Razia Sultana, Shashidhar Buggi, Nagasuma Chandra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/14f1baa617b64fed8f99576294190403
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spelling	oai:doaj.org-article:14f1baa617b64fed8f995762941904032021-12-02T15:10:32ZMeta-analysis of host response networks identifies a common core in tuberculosis10.1038/s41540-017-0005-42056-7189https://doaj.org/article/14f1baa617b64fed8f995762941904032017-02-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0005-4https://doaj.org/toc/2056-7189Tuberculosis: an underlying common-core host response network Patients suffering from tuberculosis (TB) show a high extent of variations in their gene expression patterns. Such heterogeneity poses major road blocks to our understanding of how hosts respond to the disease. A number of studies have profiled transcriptomes of human blood samples from TB patients, but a meta-analysis indicates that very few changes are consistently seen. The problem, to a large extent, lies with the way large data is analysed. We have used a genome-wide network approach to characterise the host response and have identified a common-core in the TB response networks of different patients, indicating the presence of unified host response mechanisms. This core network provides a comprehensive view into the most significant regulators of the infection-mediated biological processes across patients from different populations, and it shows partial reversals upon treatment.Awanti SambareyAbhinandan DevaprasadPriyanka BaloniMadhulika MishraAbhilash MohanPriyanka TyagiAmit SinghJS AkshataRazia SultanaShashidhar BuggiNagasuma ChandraNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Awanti Sambarey Abhinandan Devaprasad Priyanka Baloni Madhulika Mishra Abhilash Mohan Priyanka Tyagi Amit Singh JS Akshata Razia Sultana Shashidhar Buggi Nagasuma Chandra Meta-analysis of host response networks identifies a common core in tuberculosis
description	Tuberculosis: an underlying common-core host response network Patients suffering from tuberculosis (TB) show a high extent of variations in their gene expression patterns. Such heterogeneity poses major road blocks to our understanding of how hosts respond to the disease. A number of studies have profiled transcriptomes of human blood samples from TB patients, but a meta-analysis indicates that very few changes are consistently seen. The problem, to a large extent, lies with the way large data is analysed. We have used a genome-wide network approach to characterise the host response and have identified a common-core in the TB response networks of different patients, indicating the presence of unified host response mechanisms. This core network provides a comprehensive view into the most significant regulators of the infection-mediated biological processes across patients from different populations, and it shows partial reversals upon treatment.
format	article
author	Awanti Sambarey Abhinandan Devaprasad Priyanka Baloni Madhulika Mishra Abhilash Mohan Priyanka Tyagi Amit Singh JS Akshata Razia Sultana Shashidhar Buggi Nagasuma Chandra
author_facet	Awanti Sambarey Abhinandan Devaprasad Priyanka Baloni Madhulika Mishra Abhilash Mohan Priyanka Tyagi Amit Singh JS Akshata Razia Sultana Shashidhar Buggi Nagasuma Chandra
author_sort	Awanti Sambarey
title	Meta-analysis of host response networks identifies a common core in tuberculosis
title_short	Meta-analysis of host response networks identifies a common core in tuberculosis
title_full	Meta-analysis of host response networks identifies a common core in tuberculosis
title_fullStr	Meta-analysis of host response networks identifies a common core in tuberculosis
title_full_unstemmed	Meta-analysis of host response networks identifies a common core in tuberculosis
title_sort	meta-analysis of host response networks identifies a common core in tuberculosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14f1baa617b64fed8f99576294190403
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Meta-analysis of host response networks identifies a common core in tuberculosis

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