Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

Abstract Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of tradi...

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Autores principales:	Menglu Zhu, Yi Shi, Yifan Shan, Junyan Guo, Xuelong Song, Yuhua Wu, Miaolian Wu, Yan Lu, Wei Chen, Xiaoling Xu, Longguang Tang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	MPDA Nanodrug delivery systems Photothermal therapy Cancer theranostics Immunotherapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/14f71a9bfa4541eeb97302b370edb2a6
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spelling	oai:doaj.org-article:14f71a9bfa4541eeb97302b370edb2a62021-11-28T12:26:48ZRecent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics10.1186/s12951-021-01131-91477-3155https://doaj.org/article/14f71a9bfa4541eeb97302b370edb2a62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01131-9https://doaj.org/toc/1477-3155Abstract Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems. Graphical AbstractMenglu ZhuYi ShiYifan ShanJunyan GuoXuelong SongYuhua WuMiaolian WuYan LuWei ChenXiaoling XuLongguang TangBMCarticleMPDANanodrug delivery systemsPhotothermal therapyCancer theranosticsImmunotherapyBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MPDA Nanodrug delivery systems Photothermal therapy Cancer theranostics Immunotherapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	MPDA Nanodrug delivery systems Photothermal therapy Cancer theranostics Immunotherapy Biotechnology TP248.13-248.65 Medical technology R855-855.5 Menglu Zhu Yi Shi Yifan Shan Junyan Guo Xuelong Song Yuhua Wu Miaolian Wu Yan Lu Wei Chen Xiaoling Xu Longguang Tang Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
description	Abstract Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems. Graphical Abstract
format	article
author	Menglu Zhu Yi Shi Yifan Shan Junyan Guo Xuelong Song Yuhua Wu Miaolian Wu Yan Lu Wei Chen Xiaoling Xu Longguang Tang
author_facet	Menglu Zhu Yi Shi Yifan Shan Junyan Guo Xuelong Song Yuhua Wu Miaolian Wu Yan Lu Wei Chen Xiaoling Xu Longguang Tang
author_sort	Menglu Zhu
title	Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
title_short	Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
title_full	Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
title_fullStr	Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
title_full_unstemmed	Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
title_sort	recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics
publisher	BMC
publishDate	2021
url	https://doaj.org/article/14f71a9bfa4541eeb97302b370edb2a6
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Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

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