Canine mast cell tumors: diagnosis, treatment, and prognosis

Laura D Garrett Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA Abstract: Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are cur...

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Autor principal:	Garrett LD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/14f727622b4c4e98ab189e6b9ae48f6f
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spelling	oai:doaj.org-article:14f727622b4c4e98ab189e6b9ae48f6f2021-12-02T05:17:51ZCanine mast cell tumors: diagnosis, treatment, and prognosis2230-2034https://doaj.org/article/14f727622b4c4e98ab189e6b9ae48f6f2014-08-01T00:00:00Zhttp://www.dovepress.com/canine-mast-cell-tumors-diagnosis-treatment-and-prognosis-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034 Laura D Garrett Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA Abstract: Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are cured with appropriate local therapy, but a subset shows malignant behavior with the potential to spread to lymph nodes, liver, spleen, and other areas and to thus become a systemic cancer. Because of this variable behavior, it is difficult to predict how any individual tumor is going to behave. The variability thus creates uncertainty in deciding what a particular dog's prognosis is, whether staging tests to assess for metastasis are needed, and even what treatments will be necessary for best outcome. In addition to controversies over the potential for development of systemic disease, or diffuse metastasis, controversies also exist over what treatment is needed to best attain local control of these tumors. This article will briefly discuss the diagnosis of MCTs in dogs and will summarize the literature in regards to the controversial topics surrounding the more aggressive form of this disease, with recommendations made based on published studies. Keywords: mitotic index, mastocytosis, tyrosine kinase inhibitor, histologic gradeGarrett LDDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2014, Iss default, Pp 49-58 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Garrett LD Canine mast cell tumors: diagnosis, treatment, and prognosis
description	Laura D Garrett Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA Abstract: Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are cured with appropriate local therapy, but a subset shows malignant behavior with the potential to spread to lymph nodes, liver, spleen, and other areas and to thus become a systemic cancer. Because of this variable behavior, it is difficult to predict how any individual tumor is going to behave. The variability thus creates uncertainty in deciding what a particular dog's prognosis is, whether staging tests to assess for metastasis are needed, and even what treatments will be necessary for best outcome. In addition to controversies over the potential for development of systemic disease, or diffuse metastasis, controversies also exist over what treatment is needed to best attain local control of these tumors. This article will briefly discuss the diagnosis of MCTs in dogs and will summarize the literature in regards to the controversial topics surrounding the more aggressive form of this disease, with recommendations made based on published studies. Keywords: mitotic index, mastocytosis, tyrosine kinase inhibitor, histologic grade
format	article
author	Garrett LD
author_facet	Garrett LD
author_sort	Garrett LD
title	Canine mast cell tumors: diagnosis, treatment, and prognosis
title_short	Canine mast cell tumors: diagnosis, treatment, and prognosis
title_full	Canine mast cell tumors: diagnosis, treatment, and prognosis
title_fullStr	Canine mast cell tumors: diagnosis, treatment, and prognosis
title_full_unstemmed	Canine mast cell tumors: diagnosis, treatment, and prognosis
title_sort	canine mast cell tumors: diagnosis, treatment, and prognosis
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/14f727622b4c4e98ab189e6b9ae48f6f
work_keys_str_mv	AT garrettld caninemastcelltumorsdiagnosistreatmentandprognosis
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Canine mast cell tumors: diagnosis, treatment, and prognosis

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