Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model

Abstract The ergot alkaloid ergotamine is produced by Claviceps purpurea, a parasitic fungus that commonly infects crops and pastures of high agricultural and economic importance. In humans and livestock, symptoms of ergotism include necrosis and gangrene, high blood pressure, heart rate, thermoregu...

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Autores principales:	Priyanka Reddy, Delphine Vincent, Joanne Hemsworth, Vilnis Ezernieks, Kathryn Guthridge, German C. Spangenberg, Simone J. Rochfort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14fa347ded714ab1a9da62d30f5729d3
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spelling	oai:doaj.org-article:14fa347ded714ab1a9da62d30f5729d32021-12-02T17:18:21ZEffects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model10.1038/s41598-021-98870-42045-2322https://doaj.org/article/14fa347ded714ab1a9da62d30f5729d32021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98870-4https://doaj.org/toc/2045-2322Abstract The ergot alkaloid ergotamine is produced by Claviceps purpurea, a parasitic fungus that commonly infects crops and pastures of high agricultural and economic importance. In humans and livestock, symptoms of ergotism include necrosis and gangrene, high blood pressure, heart rate, thermoregulatory dysfunction and hallucinations. However, ergotamine is also used in pharmaceutical applications to treat migraines and stop post-partum hemorrhage. To define its effects, metabolomic profiling of the brain was undertaken to determine pathways perturbed by ergotamine treatment. Metabolomic profiling identified the brainstem and cerebral cortex as regions with greatest variation. In the brainstem, dysregulation of the neurotransmitter epinephrine, and the psychoactive compound 2-arachidonylglycerol was identified. In the cerebral cortex, energy related metabolites isobutyryl-L-carnitine and S-3-oxodecanoyl cysteamine were affected and concentrations of adenylosuccinate, a metabolite associated with mental retardation, were higher. This study demonstrates, for the first time, key metabolomic pathways involved in the behavioural and physiological dysfunction of ergot alkaloid intoxicated animals.Priyanka ReddyDelphine VincentJoanne HemsworthVilnis EzernieksKathryn GuthridgeGerman C. SpangenbergSimone J. RochfortNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Priyanka Reddy Delphine Vincent Joanne Hemsworth Vilnis Ezernieks Kathryn Guthridge German C. Spangenberg Simone J. Rochfort Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
description	Abstract The ergot alkaloid ergotamine is produced by Claviceps purpurea, a parasitic fungus that commonly infects crops and pastures of high agricultural and economic importance. In humans and livestock, symptoms of ergotism include necrosis and gangrene, high blood pressure, heart rate, thermoregulatory dysfunction and hallucinations. However, ergotamine is also used in pharmaceutical applications to treat migraines and stop post-partum hemorrhage. To define its effects, metabolomic profiling of the brain was undertaken to determine pathways perturbed by ergotamine treatment. Metabolomic profiling identified the brainstem and cerebral cortex as regions with greatest variation. In the brainstem, dysregulation of the neurotransmitter epinephrine, and the psychoactive compound 2-arachidonylglycerol was identified. In the cerebral cortex, energy related metabolites isobutyryl-L-carnitine and S-3-oxodecanoyl cysteamine were affected and concentrations of adenylosuccinate, a metabolite associated with mental retardation, were higher. This study demonstrates, for the first time, key metabolomic pathways involved in the behavioural and physiological dysfunction of ergot alkaloid intoxicated animals.
format	article
author	Priyanka Reddy Delphine Vincent Joanne Hemsworth Vilnis Ezernieks Kathryn Guthridge German C. Spangenberg Simone J. Rochfort
author_facet	Priyanka Reddy Delphine Vincent Joanne Hemsworth Vilnis Ezernieks Kathryn Guthridge German C. Spangenberg Simone J. Rochfort
author_sort	Priyanka Reddy
title	Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
title_short	Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
title_full	Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
title_fullStr	Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
title_full_unstemmed	Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
title_sort	effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/14fa347ded714ab1a9da62d30f5729d3
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Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model

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