Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in m...

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Autores principales:	Teresa Pérez-Berezo, Julien Pujo, Patricia Martin, Pauline Le Faouder, Jean-Marie Galano, Alexandre Guy, Claude Knauf, Jean Claude Tabet, Sophie Tronnet, Frederick Barreau, Maud Heuillet, Gilles Dietrich, Justine Bertrand-Michel, Thierry Durand, Eric Oswald, Nicolas Cenac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14fbaec632884e6fbafc02bc5cea62fa
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spelling	oai:doaj.org-article:14fbaec632884e6fbafc02bc5cea62fa2021-12-02T17:06:14ZIdentification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 191710.1038/s41467-017-01403-92041-1723https://doaj.org/article/14fbaec632884e6fbafc02bc5cea62fa2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01403-9https://doaj.org/toc/2041-1723Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.Teresa Pérez-BerezoJulien PujoPatricia MartinPauline Le FaouderJean-Marie GalanoAlexandre GuyClaude KnaufJean Claude TabetSophie TronnetFrederick BarreauMaud HeuilletGilles DietrichJustine Bertrand-MichelThierry DurandEric OswaldNicolas CenacNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teresa Pérez-Berezo Julien Pujo Patricia Martin Pauline Le Faouder Jean-Marie Galano Alexandre Guy Claude Knauf Jean Claude Tabet Sophie Tronnet Frederick Barreau Maud Heuillet Gilles Dietrich Justine Bertrand-Michel Thierry Durand Eric Oswald Nicolas Cenac Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
description	Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.
format	article
author	Teresa Pérez-Berezo Julien Pujo Patricia Martin Pauline Le Faouder Jean-Marie Galano Alexandre Guy Claude Knauf Jean Claude Tabet Sophie Tronnet Frederick Barreau Maud Heuillet Gilles Dietrich Justine Bertrand-Michel Thierry Durand Eric Oswald Nicolas Cenac
author_facet	Teresa Pérez-Berezo Julien Pujo Patricia Martin Pauline Le Faouder Jean-Marie Galano Alexandre Guy Claude Knauf Jean Claude Tabet Sophie Tronnet Frederick Barreau Maud Heuillet Gilles Dietrich Justine Bertrand-Michel Thierry Durand Eric Oswald Nicolas Cenac
author_sort	Teresa Pérez-Berezo
title	Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_short	Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_full	Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_fullStr	Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_full_unstemmed	Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917
title_sort	identification of an analgesic lipopeptide produced by the probiotic escherichia coli strain nissle 1917
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14fbaec632884e6fbafc02bc5cea62fa
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Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

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