DNA Methylation and Schizophrenia: Current Literature and Future Perspective

Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea, identity, and emotions. It has no central pathophysiological mechanism and precise diagnostic markers. Despite its high heritability, there are also environmental factors implicated in the development of sc...

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Autores principales:	Thabo Magwai, Khanyiso Bright Shangase, Fredrick Otieno Oginga, Bonginkosi Chiliza, Thabisile Mpofana, Khethelo Richman Xulu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	schizophrenia DNA methylation epigenetics biomarkers Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/14fdc79e94de4fa8b48b63c08258c27e
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spelling	oai:doaj.org-article:14fdc79e94de4fa8b48b63c08258c27e2021-11-25T17:08:34ZDNA Methylation and Schizophrenia: Current Literature and Future Perspective10.3390/cells101128902073-4409https://doaj.org/article/14fdc79e94de4fa8b48b63c08258c27e2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2890https://doaj.org/toc/2073-4409Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea, identity, and emotions. It has no central pathophysiological mechanism and precise diagnostic markers. Despite its high heritability, there are also environmental factors implicated in the development of schizophrenia. Epigenetic factors are thought to mediate the effects of environmental factors in the development of the disorder. Epigenetic modifications like DNA methylation are a risk factor for schizophrenia. Targeted gene approach studies attempted to find candidate gene methylation, but the results are contradictory. Genome-wide methylation studies are insufficient in literature and the available data do not cover different populations like the African populations. The current genome-wide studies have limitations related to the sample and methods used. Studies are required to control for these limitations. Integration of DNA methylation, gene expression, and their effects are important in the understanding of the development of schizophrenia and search for biomarkers. There are currently no precise and functional biomarkers for the disorder. Several epigenetic markers have been reported to be common in functional and peripheral tissue. This makes the peripheral tissue epigenetic changes a surrogate of functional tissue, suggesting common epigenetic alteration can be used as biomarkers of schizophrenia in peripheral tissue.Thabo MagwaiKhanyiso Bright ShangaseFredrick Otieno OgingaBonginkosi ChilizaThabisile MpofanaKhethelo Richman XuluMDPI AGarticleschizophreniaDNA methylationepigeneticsbiomarkersBiology (General)QH301-705.5ENCells, Vol 10, Iss 2890, p 2890 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia DNA methylation epigenetics biomarkers Biology (General) QH301-705.5
spellingShingle	schizophrenia DNA methylation epigenetics biomarkers Biology (General) QH301-705.5 Thabo Magwai Khanyiso Bright Shangase Fredrick Otieno Oginga Bonginkosi Chiliza Thabisile Mpofana Khethelo Richman Xulu DNA Methylation and Schizophrenia: Current Literature and Future Perspective
description	Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea, identity, and emotions. It has no central pathophysiological mechanism and precise diagnostic markers. Despite its high heritability, there are also environmental factors implicated in the development of schizophrenia. Epigenetic factors are thought to mediate the effects of environmental factors in the development of the disorder. Epigenetic modifications like DNA methylation are a risk factor for schizophrenia. Targeted gene approach studies attempted to find candidate gene methylation, but the results are contradictory. Genome-wide methylation studies are insufficient in literature and the available data do not cover different populations like the African populations. The current genome-wide studies have limitations related to the sample and methods used. Studies are required to control for these limitations. Integration of DNA methylation, gene expression, and their effects are important in the understanding of the development of schizophrenia and search for biomarkers. There are currently no precise and functional biomarkers for the disorder. Several epigenetic markers have been reported to be common in functional and peripheral tissue. This makes the peripheral tissue epigenetic changes a surrogate of functional tissue, suggesting common epigenetic alteration can be used as biomarkers of schizophrenia in peripheral tissue.
format	article
author	Thabo Magwai Khanyiso Bright Shangase Fredrick Otieno Oginga Bonginkosi Chiliza Thabisile Mpofana Khethelo Richman Xulu
author_facet	Thabo Magwai Khanyiso Bright Shangase Fredrick Otieno Oginga Bonginkosi Chiliza Thabisile Mpofana Khethelo Richman Xulu
author_sort	Thabo Magwai
title	DNA Methylation and Schizophrenia: Current Literature and Future Perspective
title_short	DNA Methylation and Schizophrenia: Current Literature and Future Perspective
title_full	DNA Methylation and Schizophrenia: Current Literature and Future Perspective
title_fullStr	DNA Methylation and Schizophrenia: Current Literature and Future Perspective
title_full_unstemmed	DNA Methylation and Schizophrenia: Current Literature and Future Perspective
title_sort	dna methylation and schizophrenia: current literature and future perspective
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/14fdc79e94de4fa8b48b63c08258c27e
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DNA Methylation and Schizophrenia: Current Literature and Future Perspective

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