Blood substitution therapy rescues the brain of mice from ischemic damage

Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.

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Autores principales: Xuefang Ren, Heng Hu, Imran Farooqi, James W. Simpkins
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa
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spelling oai:doaj.org-article:1502a30d56c64a088690f9f1ea34f7aa2021-12-02T16:34:56ZBlood substitution therapy rescues the brain of mice from ischemic damage10.1038/s41467-020-17930-x2041-1723https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17930-xhttps://doaj.org/toc/2041-1723Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.Xuefang RenHeng HuImran FarooqiJames W. SimpkinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuefang Ren
Heng Hu
Imran Farooqi
James W. Simpkins
Blood substitution therapy rescues the brain of mice from ischemic damage
description Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.
format article
author Xuefang Ren
Heng Hu
Imran Farooqi
James W. Simpkins
author_facet Xuefang Ren
Heng Hu
Imran Farooqi
James W. Simpkins
author_sort Xuefang Ren
title Blood substitution therapy rescues the brain of mice from ischemic damage
title_short Blood substitution therapy rescues the brain of mice from ischemic damage
title_full Blood substitution therapy rescues the brain of mice from ischemic damage
title_fullStr Blood substitution therapy rescues the brain of mice from ischemic damage
title_full_unstemmed Blood substitution therapy rescues the brain of mice from ischemic damage
title_sort blood substitution therapy rescues the brain of mice from ischemic damage
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa
work_keys_str_mv AT xuefangren bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage
AT henghu bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage
AT imranfarooqi bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage
AT jameswsimpkins bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage
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