Blood substitution therapy rescues the brain of mice from ischemic damage
Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.
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Nature Portfolio
2020
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oai:doaj.org-article:1502a30d56c64a088690f9f1ea34f7aa2021-12-02T16:34:56ZBlood substitution therapy rescues the brain of mice from ischemic damage10.1038/s41467-020-17930-x2041-1723https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17930-xhttps://doaj.org/toc/2041-1723Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.Xuefang RenHeng HuImran FarooqiJames W. SimpkinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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Science Q Xuefang Ren Heng Hu Imran Farooqi James W. Simpkins Blood substitution therapy rescues the brain of mice from ischemic damage |
description |
Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits. |
format |
article |
author |
Xuefang Ren Heng Hu Imran Farooqi James W. Simpkins |
author_facet |
Xuefang Ren Heng Hu Imran Farooqi James W. Simpkins |
author_sort |
Xuefang Ren |
title |
Blood substitution therapy rescues the brain of mice from ischemic damage |
title_short |
Blood substitution therapy rescues the brain of mice from ischemic damage |
title_full |
Blood substitution therapy rescues the brain of mice from ischemic damage |
title_fullStr |
Blood substitution therapy rescues the brain of mice from ischemic damage |
title_full_unstemmed |
Blood substitution therapy rescues the brain of mice from ischemic damage |
title_sort |
blood substitution therapy rescues the brain of mice from ischemic damage |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa |
work_keys_str_mv |
AT xuefangren bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage AT henghu bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage AT imranfarooqi bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage AT jameswsimpkins bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage |
_version_ |
1718383736628707328 |