Blood substitution therapy rescues the brain of mice from ischemic damage

Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.

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Bibliographic Details
Main Authors:	Xuefang Ren, Heng Hu, Imran Farooqi, James W. Simpkins
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa
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spelling	oai:doaj.org-article:1502a30d56c64a088690f9f1ea34f7aa2021-12-02T16:34:56ZBlood substitution therapy rescues the brain of mice from ischemic damage10.1038/s41467-020-17930-x2041-1723https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17930-xhttps://doaj.org/toc/2041-1723Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.Xuefang RenHeng HuImran FarooqiJames W. SimpkinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuefang Ren Heng Hu Imran Farooqi James W. Simpkins Blood substitution therapy rescues the brain of mice from ischemic damage
description	Acute stroke causes complex, pathological, and systemic responses which remain challenging to treat. Here, the authors show that substituting the blood of stroke model mice with whole-blood from naive healthy donor mice reduces infarct volume and improves neurological deficits.
format	article
author	Xuefang Ren Heng Hu Imran Farooqi James W. Simpkins
author_facet	Xuefang Ren Heng Hu Imran Farooqi James W. Simpkins
author_sort	Xuefang Ren
title	Blood substitution therapy rescues the brain of mice from ischemic damage
title_short	Blood substitution therapy rescues the brain of mice from ischemic damage
title_full	Blood substitution therapy rescues the brain of mice from ischemic damage
title_fullStr	Blood substitution therapy rescues the brain of mice from ischemic damage
title_full_unstemmed	Blood substitution therapy rescues the brain of mice from ischemic damage
title_sort	blood substitution therapy rescues the brain of mice from ischemic damage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1502a30d56c64a088690f9f1ea34f7aa
work_keys_str_mv	AT xuefangren bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage AT henghu bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage AT imranfarooqi bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage AT jameswsimpkins bloodsubstitutiontherapyrescuesthebrainofmicefromischemicdamage
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Blood substitution therapy rescues the brain of mice from ischemic damage

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