Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lili Chen, Valentina Strohmeier, Zhengxiang He, Madhura Deshpande, Jovani Catalan-Dibene, Scott K. Durum, Thomas M. Moran, Thomas Kraus, Huabao Xiong, Jeremiah J. Faith, Chhinder P. Sodhi, David J. Hackam, Sergio A. Lira, Glaucia C. Furtado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/150545e2c5bb47c5b26ec7e4a3893f65
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:150545e2c5bb47c5b26ec7e4a3893f65
record_format	dspace
spelling	oai:doaj.org-article:150545e2c5bb47c5b26ec7e4a3893f652021-12-02T14:38:45ZInterleukin 22 disrupts pancreatic function in newborn mice expressing IL-2310.1038/s41467-019-12540-82041-1723https://doaj.org/article/150545e2c5bb47c5b26ec7e4a3893f652019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12540-8https://doaj.org/toc/2041-1723Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22, which directly suppresses pancreatic cell differentiation.Lili ChenValentina StrohmeierZhengxiang HeMadhura DeshpandeJovani Catalan-DibeneScott K. DurumThomas M. MoranThomas KrausHuabao XiongJeremiah J. FaithChhinder P. SodhiDavid J. HackamSergio A. LiraGlaucia C. FurtadoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lili Chen Valentina Strohmeier Zhengxiang He Madhura Deshpande Jovani Catalan-Dibene Scott K. Durum Thomas M. Moran Thomas Kraus Huabao Xiong Jeremiah J. Faith Chhinder P. Sodhi David J. Hackam Sergio A. Lira Glaucia C. Furtado Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
description	Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22, which directly suppresses pancreatic cell differentiation.
format	article
author	Lili Chen Valentina Strohmeier Zhengxiang He Madhura Deshpande Jovani Catalan-Dibene Scott K. Durum Thomas M. Moran Thomas Kraus Huabao Xiong Jeremiah J. Faith Chhinder P. Sodhi David J. Hackam Sergio A. Lira Glaucia C. Furtado
author_facet	Lili Chen Valentina Strohmeier Zhengxiang He Madhura Deshpande Jovani Catalan-Dibene Scott K. Durum Thomas M. Moran Thomas Kraus Huabao Xiong Jeremiah J. Faith Chhinder P. Sodhi David J. Hackam Sergio A. Lira Glaucia C. Furtado
author_sort	Lili Chen
title	Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
title_short	Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
title_full	Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
title_fullStr	Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
title_full_unstemmed	Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
title_sort	interleukin 22 disrupts pancreatic function in newborn mice expressing il-23
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/150545e2c5bb47c5b26ec7e4a3893f65
work_keys_str_mv	AT lilichen interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT valentinastrohmeier interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT zhengxianghe interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT madhuradeshpande interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT jovanicatalandibene interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT scottkdurum interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT thomasmmoran interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT thomaskraus interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT huabaoxiong interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT jeremiahjfaith interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT chhinderpsodhi interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT davidjhackam interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT sergioalira interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23 AT glauciacfurtado interleukin22disruptspancreaticfunctioninnewbornmiceexpressingil23
_version_	1718390876836724736

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

Ejemplares similares