Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22,...

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Main Authors: Lili Chen, Valentina Strohmeier, Zhengxiang He, Madhura Deshpande, Jovani Catalan-Dibene, Scott K. Durum, Thomas M. Moran, Thomas Kraus, Huabao Xiong, Jeremiah J. Faith, Chhinder P. Sodhi, David J. Hackam, Sergio A. Lira, Glaucia C. Furtado
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/150545e2c5bb47c5b26ec7e4a3893f65
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https://doaj.org/article/150545e2c5bb47c5b26ec7e4a3893f65

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