Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent. Aim of the work: The study aimed to evaluate the nasal and...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Al-Azhar University, Faculty of Medicine (Damietta)
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/1507f864ee2e4ccbb3e5ea8c133b17f9 |
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| Sumario: | Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent. Aim of the work: The study aimed to evaluate the nasal and salivary pepsin as a biomarker for GER in CRS patients. Patients and Methods: Fifty patients with CRS were included; 28 males and 22 females, and 50 healthy volunteers; 25 males and 25 females served as controls. Peptest was performed for all subjects. Results: Pepsin positivity was found to have a slight increase in CRS salivary samples than the control group. However, the difference was insignificant [P >0.05], in contrast with nasal samples, which was estimated to have a statistically significant difference [P <0.05] in the second and third samples. As regard pepsin concentration in salivary samples, it was found to show a statistically significant difference [P <0.01] in all samples, while it was non-significant in all nasal samples [P>0.05]. Conclusion: CRS patients have a higher positive rate of pepsin in salivary and nasal secretions; however, no significant more pepsin in saliva or nasal secretions is regarded as CRS-patients than healthy controls. |
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