Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker

Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent. Aim of the work: The study aimed to evaluate the nasal and...

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Auteurs principaux:	Mohamed Abdelazim, Ahmed Ibrahim, Amr El-hakeem
Format:	article
Langue:	EN
Publié:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Sujets:	chronic rhinosinusitis salivary nasal pepsin gastroesophageal reflux disease Medicine (General) R5-920
Accès en ligne:	https://doaj.org/article/1507f864ee2e4ccbb3e5ea8c133b17f9
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spelling	oai:doaj.org-article:1507f864ee2e4ccbb3e5ea8c133b17f92021-12-02T15:42:54ZAssociation between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker2636-41742682-378010.21608/ijma.2021.47667.1197https://doaj.org/article/1507f864ee2e4ccbb3e5ea8c133b17f92021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_140633_b86cb44224c8055c579d710e708bbb54.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent. Aim of the work: The study aimed to evaluate the nasal and salivary pepsin as a biomarker for GER in CRS patients. Patients and Methods: Fifty patients with CRS were included; 28 males and 22 females, and 50 healthy volunteers; 25 males and 25 females served as controls. Peptest was performed for all subjects. Results: Pepsin positivity was found to have a slight increase in CRS salivary samples than the control group. However, the difference was insignificant [P >0.05], in contrast with nasal samples, which was estimated to have a statistically significant difference [P <0.05] in the second and third samples. As regard pepsin concentration in salivary samples, it was found to show a statistically significant difference [P <0.01] in all samples, while it was non-significant in all nasal samples [P>0.05]. Conclusion: CRS patients have a higher positive rate of pepsin in salivary and nasal secretions; however, no significant more pepsin in saliva or nasal secretions is regarded as CRS-patients than healthy controls.Mohamed AbdelazimAhmed IbrahimAmr El-hakeemAl-Azhar University, Faculty of Medicine (Damietta)articlechronic rhinosinusitissalivarynasalpepsingastroesophageal reflux diseaseMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1181-1187 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic rhinosinusitis salivary nasal pepsin gastroesophageal reflux disease Medicine (General) R5-920
spellingShingle	chronic rhinosinusitis salivary nasal pepsin gastroesophageal reflux disease Medicine (General) R5-920 Mohamed Abdelazim Ahmed Ibrahim Amr El-hakeem Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
description	Background: The relationship between gastroesophageal reflux [GER] and chronic rhinosinusitis [CRS] has been discussed in several studies, but a direct relationship could not be established. However, both conditions are highly prevalent. Aim of the work: The study aimed to evaluate the nasal and salivary pepsin as a biomarker for GER in CRS patients. Patients and Methods: Fifty patients with CRS were included; 28 males and 22 females, and 50 healthy volunteers; 25 males and 25 females served as controls. Peptest was performed for all subjects. Results: Pepsin positivity was found to have a slight increase in CRS salivary samples than the control group. However, the difference was insignificant [P >0.05], in contrast with nasal samples, which was estimated to have a statistically significant difference [P <0.05] in the second and third samples. As regard pepsin concentration in salivary samples, it was found to show a statistically significant difference [P <0.01] in all samples, while it was non-significant in all nasal samples [P>0.05]. Conclusion: CRS patients have a higher positive rate of pepsin in salivary and nasal secretions; however, no significant more pepsin in saliva or nasal secretions is regarded as CRS-patients than healthy controls.
format	article
author	Mohamed Abdelazim Ahmed Ibrahim Amr El-hakeem
author_facet	Mohamed Abdelazim Ahmed Ibrahim Amr El-hakeem
author_sort	Mohamed Abdelazim
title	Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
title_short	Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
title_full	Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
title_fullStr	Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
title_full_unstemmed	Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker
title_sort	association between gastroesophageal reflux disease and chronic sinusitis: salivary and nasal pepsin as a biomarker
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/1507f864ee2e4ccbb3e5ea8c133b17f9
work_keys_str_mv	AT mohamedabdelazim associationbetweengastroesophagealrefluxdiseaseandchronicsinusitissalivaryandnasalpepsinasabiomarker AT ahmedibrahim associationbetweengastroesophagealrefluxdiseaseandchronicsinusitissalivaryandnasalpepsinasabiomarker AT amrelhakeem associationbetweengastroesophagealrefluxdiseaseandchronicsinusitissalivaryandnasalpepsinasabiomarker
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Association between Gastroesophageal Reflux Disease and Chronic Sinusitis: Salivary and Nasal Pepsin as a Biomarker

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