Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics

Abstract Indocyanine green (ICG) is a clinically approved dye that has shown great promise as a phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it has certain limitations, such as poor photostability and non-specific binding...

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Autores principales:	Yong-Deok Lee, Hyeon Jeong Shin, Jounghyun Yoo, Gayoung Kim, Min-Kyoung Kang, Jae Jun Lee, Joona Bang, Jin-Kyoung Yang, Sehoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Indocyanine green Metal complex Dual-modal imaging Photothermal therapy Theranostics Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Science Q Physics QC1-999
Acceso en línea:	https://doaj.org/article/1507fa5a549e444e8fff5f11ce3e1bc9
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spelling	oai:doaj.org-article:1507fa5a549e444e8fff5f11ce3e1bc92021-11-14T12:37:40ZMetal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics10.1186/s40580-021-00286-32196-5404https://doaj.org/article/1507fa5a549e444e8fff5f11ce3e1bc92021-11-01T00:00:00Zhttps://doi.org/10.1186/s40580-021-00286-3https://doaj.org/toc/2196-5404Abstract Indocyanine green (ICG) is a clinically approved dye that has shown great promise as a phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it has certain limitations, such as poor photostability and non-specific binding to serum proteins, subjected to rapid clearance and decreased theranostic efficacy in vivo. This study reports stable and biocompatible nanoparticles of ICG (ICG-Fe NPs) where ICG is electrostatically complexed with an endogenously abundant metal ion (Fe3+) and subsequently nanoformulated with a clinically approved polymer surfactant, Pluronic F127. Under near-infrared laser irradiation, ICG-Fe NPs were found to be more effective for photothermal temperature elevation than free ICG molecules owing to the improved photostability. In addition, ICG-Fe NPs showed the markedly enhanced tumor targeting and visualization with photoacoustic/fluorescent signaling upon intravenous injection, attributed to the stable metal complexation that prevents ICG-Fe NPs from releasing free ICG before tumor targeting. Under dual-modal imaging guidance, ICG-Fe NPs could successfully potentiate photothermal therapy of cancer by applying near-infrared laser irradiation, holding potential as a promising nanomedicine composed of all biocompatible ingredients for clinically relevant phototheranostics.Yong-Deok LeeHyeon Jeong ShinJounghyun YooGayoung KimMin-Kyoung KangJae Jun LeeJoona BangJin-Kyoung YangSehoon KimSpringerOpenarticleIndocyanine greenMetal complexDual-modal imagingPhotothermal therapyTheranosticsTechnologyTChemical technologyTP1-1185BiotechnologyTP248.13-248.65ScienceQPhysicsQC1-999ENNano Convergence, Vol 8, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Indocyanine green Metal complex Dual-modal imaging Photothermal therapy Theranostics Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Science Q Physics QC1-999
spellingShingle	Indocyanine green Metal complex Dual-modal imaging Photothermal therapy Theranostics Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Science Q Physics QC1-999 Yong-Deok Lee Hyeon Jeong Shin Jounghyun Yoo Gayoung Kim Min-Kyoung Kang Jae Jun Lee Joona Bang Jin-Kyoung Yang Sehoon Kim Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
description	Abstract Indocyanine green (ICG) is a clinically approved dye that has shown great promise as a phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it has certain limitations, such as poor photostability and non-specific binding to serum proteins, subjected to rapid clearance and decreased theranostic efficacy in vivo. This study reports stable and biocompatible nanoparticles of ICG (ICG-Fe NPs) where ICG is electrostatically complexed with an endogenously abundant metal ion (Fe3+) and subsequently nanoformulated with a clinically approved polymer surfactant, Pluronic F127. Under near-infrared laser irradiation, ICG-Fe NPs were found to be more effective for photothermal temperature elevation than free ICG molecules owing to the improved photostability. In addition, ICG-Fe NPs showed the markedly enhanced tumor targeting and visualization with photoacoustic/fluorescent signaling upon intravenous injection, attributed to the stable metal complexation that prevents ICG-Fe NPs from releasing free ICG before tumor targeting. Under dual-modal imaging guidance, ICG-Fe NPs could successfully potentiate photothermal therapy of cancer by applying near-infrared laser irradiation, holding potential as a promising nanomedicine composed of all biocompatible ingredients for clinically relevant phototheranostics.
format	article
author	Yong-Deok Lee Hyeon Jeong Shin Jounghyun Yoo Gayoung Kim Min-Kyoung Kang Jae Jun Lee Joona Bang Jin-Kyoung Yang Sehoon Kim
author_facet	Yong-Deok Lee Hyeon Jeong Shin Jounghyun Yoo Gayoung Kim Min-Kyoung Kang Jae Jun Lee Joona Bang Jin-Kyoung Yang Sehoon Kim
author_sort	Yong-Deok Lee
title	Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
title_short	Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
title_full	Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
title_fullStr	Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
title_full_unstemmed	Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
title_sort	metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/1507fa5a549e444e8fff5f11ce3e1bc9
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Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics

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