Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria

Late detection of Breast cancer(BC) and progressing with advanced-stage diagnosis after early detection contribute differently to the challenges of managing BC in Africa. Understanding the difference may improve cancer education programs and their effectiveness. <h4>Objective</h4> To des...

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Autores principales:	Olayide Agodirin, Samuel Olatoke, Ganiyu Rahman, Oladapo Kolawole, Saliu Oguntola, Olalekan Olasehinde, Omobolaji Ayandipo, Julius Olaogun, Aba Katung, Amarachukwu Etonyeaku, Olufemi Habeeb, Ademola Adeyeye, John Agboola, Halimat Akande, Olusola Akanbi, Oluwafemi Fatudimu, Anthony Ajiboye
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/15088fbbedb648b5b1ce0af0dce003b4
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spelling	oai:doaj.org-article:15088fbbedb648b5b1ce0af0dce003b42021-11-11T06:44:16ZDeterminants of late detection and advanced-stage diagnosis of breast cancer in Nigeria1932-6203https://doaj.org/article/15088fbbedb648b5b1ce0af0dce003b42021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565753/?tool=EBIhttps://doaj.org/toc/1932-6203Late detection of Breast cancer(BC) and progressing with advanced-stage diagnosis after early detection contribute differently to the challenges of managing BC in Africa. Understanding the difference may improve cancer education programs and their effectiveness. <h4>Objective</h4> To describe the risk factors for late detection and advanced-stage diagnosis among patients who detected their BC early. <h4>Method</h4> Using secondary data, we analyzed the impact of socio-demographic factors, premorbid experience, BC knowledge, and health-seeking pattern on the risk of late detection and advanced-stage diagnosis after early BC detection. Test of statistical significance in SPSS and EasyR was set at 5% using Sign-test, chi-square tests (of independence and goodness of fit), odds ratio, or risk ratio as appropriate. <h4>Result</h4> Most socio-demographic factors did not affect detection size or risk of disease progression in the 405 records analyzed. High BC knowledge, p-value = 0.001, and practicing breast self-examination (BSE) increased early detection, p-value = 0.04, with a higher probability (OR 1.6 (95% CI 1.1–2.5) of detecting <2cm lesions. Visiting alternative care (RR 1.5(95% CI 1.2–1.9), low BC knowledge (RR 1.3(95% CI 1.1–1.9), and registering concerns for hospital care increased the risk of advanced-stage diagnosis after early detection (64% (95% CI 55–72)). Adhering to the monthly BSE schedule reduced the risk of advanced-stage diagnosis by -25% (95% CI -49, -1.1) in the presence of socioeconomic barriers. <h4>Conclusion</h4> Strategies to increase BC knowledge and BSE may help BC downstaging, especially among women with common barriers to early diagnosis.Olayide AgodirinSamuel OlatokeGaniyu RahmanOladapo KolawoleSaliu OguntolaOlalekan OlasehindeOmobolaji AyandipoJulius OlaogunAba KatungAmarachukwu EtonyeakuOlufemi HabeebAdemola AdeyeyeJohn AgboolaHalimat AkandeOlusola AkanbiOluwafemi FatudimuAnthony AjiboyePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Olayide Agodirin Samuel Olatoke Ganiyu Rahman Oladapo Kolawole Saliu Oguntola Olalekan Olasehinde Omobolaji Ayandipo Julius Olaogun Aba Katung Amarachukwu Etonyeaku Olufemi Habeeb Ademola Adeyeye John Agboola Halimat Akande Olusola Akanbi Oluwafemi Fatudimu Anthony Ajiboye Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria
description	Late detection of Breast cancer(BC) and progressing with advanced-stage diagnosis after early detection contribute differently to the challenges of managing BC in Africa. Understanding the difference may improve cancer education programs and their effectiveness. <h4>Objective</h4> To describe the risk factors for late detection and advanced-stage diagnosis among patients who detected their BC early. <h4>Method</h4> Using secondary data, we analyzed the impact of socio-demographic factors, premorbid experience, BC knowledge, and health-seeking pattern on the risk of late detection and advanced-stage diagnosis after early BC detection. Test of statistical significance in SPSS and EasyR was set at 5% using Sign-test, chi-square tests (of independence and goodness of fit), odds ratio, or risk ratio as appropriate. <h4>Result</h4> Most socio-demographic factors did not affect detection size or risk of disease progression in the 405 records analyzed. High BC knowledge, p-value = 0.001, and practicing breast self-examination (BSE) increased early detection, p-value = 0.04, with a higher probability (OR 1.6 (95% CI 1.1–2.5) of detecting <2cm lesions. Visiting alternative care (RR 1.5(95% CI 1.2–1.9), low BC knowledge (RR 1.3(95% CI 1.1–1.9), and registering concerns for hospital care increased the risk of advanced-stage diagnosis after early detection (64% (95% CI 55–72)). Adhering to the monthly BSE schedule reduced the risk of advanced-stage diagnosis by -25% (95% CI -49, -1.1) in the presence of socioeconomic barriers. <h4>Conclusion</h4> Strategies to increase BC knowledge and BSE may help BC downstaging, especially among women with common barriers to early diagnosis.
format	article
author	Olayide Agodirin Samuel Olatoke Ganiyu Rahman Oladapo Kolawole Saliu Oguntola Olalekan Olasehinde Omobolaji Ayandipo Julius Olaogun Aba Katung Amarachukwu Etonyeaku Olufemi Habeeb Ademola Adeyeye John Agboola Halimat Akande Olusola Akanbi Oluwafemi Fatudimu Anthony Ajiboye
author_facet	Olayide Agodirin Samuel Olatoke Ganiyu Rahman Oladapo Kolawole Saliu Oguntola Olalekan Olasehinde Omobolaji Ayandipo Julius Olaogun Aba Katung Amarachukwu Etonyeaku Olufemi Habeeb Ademola Adeyeye John Agboola Halimat Akande Olusola Akanbi Oluwafemi Fatudimu Anthony Ajiboye
author_sort	Olayide Agodirin
title	Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria
title_short	Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria
title_full	Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria
title_fullStr	Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria
title_full_unstemmed	Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria
title_sort	determinants of late detection and advanced-stage diagnosis of breast cancer in nigeria
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/15088fbbedb648b5b1ce0af0dce003b4
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Determinants of late detection and advanced-stage diagnosis of breast cancer in Nigeria

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