Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds

Genetic polymorphisms significantly affect individual responses to warfarin, contributing to unpredictability and challenges in managing anticoagulation. Although numerous studies have demonstrated that pharmacogenetic testing improves anticoagulation-related outcomes in the Caucasian population, it...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Grace Shu-wen Chang, Doreen Su-Yin Tan
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/150e491982674f948c727c50f1f0fd03
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:150e491982674f948c727c50f1f0fd03
record_format	dspace
spelling	oai:doaj.org-article:150e491982674f948c727c50f1f0fd032021-12-04T16:03:15ZUsing Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds10.15420/ecr.2019.121758-37641758-3756https://doaj.org/article/150e491982674f948c727c50f1f0fd032020-06-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2019.12https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Genetic polymorphisms significantly affect individual responses to warfarin, contributing to unpredictability and challenges in managing anticoagulation. Although numerous studies have demonstrated that pharmacogenetic testing improves anticoagulation-related outcomes in the Caucasian population, its effect in the Asian population has not been well studied. This article discusses controversies surrounding tailoring warfarin therapy using pharmacogenetic testing and its role in clinical practice, with a focus on the Asian context. Using the Singapore experience as an example, the authors propose how pharmacogenetic testing can be a means to reduce dose titrations in select patient populations, and how it may be positioned as an enabler to reduce healthcare resources needed for anticoagulation management.Grace Shu-wen ChangDoreen Su-Yin TanRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 15, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Grace Shu-wen Chang Doreen Su-Yin Tan Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds
description	Genetic polymorphisms significantly affect individual responses to warfarin, contributing to unpredictability and challenges in managing anticoagulation. Although numerous studies have demonstrated that pharmacogenetic testing improves anticoagulation-related outcomes in the Caucasian population, its effect in the Asian population has not been well studied. This article discusses controversies surrounding tailoring warfarin therapy using pharmacogenetic testing and its role in clinical practice, with a focus on the Asian context. Using the Singapore experience as an example, the authors propose how pharmacogenetic testing can be a means to reduce dose titrations in select patient populations, and how it may be positioned as an enabler to reduce healthcare resources needed for anticoagulation management.
format	article
author	Grace Shu-wen Chang Doreen Su-Yin Tan
author_facet	Grace Shu-wen Chang Doreen Su-Yin Tan
author_sort	Grace Shu-wen Chang
title	Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds
title_short	Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds
title_full	Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds
title_fullStr	Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds
title_full_unstemmed	Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds
title_sort	using pharmacogenetic testing to tailor warfarin therapy: the singapore experience and what the future holds
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/150e491982674f948c727c50f1f0fd03
work_keys_str_mv	AT graceshuwenchang usingpharmacogenetictestingtotailorwarfarintherapythesingaporeexperienceandwhatthefutureholds AT doreensuyintan usingpharmacogenetictestingtotailorwarfarintherapythesingaporeexperienceandwhatthefutureholds
_version_	1718372720053321728

Using Pharmacogenetic Testing to Tailor Warfarin Therapy: The Singapore Experience and What the Future Holds

Ejemplares similares