Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review

Ganna Balagura,1,2 Antonella Riva,2 Francesca Marchese,2 Alberto Verrotti,3 Pasquale Striano1,2 1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa, Genoa, Italy; 2Pediatric Neurology and Muscular Diseases Unit, IRCCS ‘G...

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Autores principales:	Balagura G, Riva A, Marchese F, Verrotti A, Striano P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rufinamide lennox-gastaut epilepsy children Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/150e9af6e1924893a4ea1ddfc95c12ff
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spelling	oai:doaj.org-article:150e9af6e1924893a4ea1ddfc95c12ff2021-12-02T08:15:12ZAdjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review1178-2021https://doaj.org/article/150e9af6e1924893a4ea1ddfc95c12ff2020-02-01T00:00:00Zhttps://www.dovepress.com/adjunctive-rufinamide-in-children-with-lennox-gastaut-syndrome-a-liter-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ganna Balagura,1,2 Antonella Riva,2 Francesca Marchese,2 Alberto Verrotti,3 Pasquale Striano1,2 1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa, Genoa, Italy; 2Pediatric Neurology and Muscular Diseases Unit, IRCCS ‘G. Gaslini’ Institute, Genoa, Italy; 3Department of Pediatrics, University of L’Aquila, L’Aquila, ItalyCorrespondence: Pasquale Striano Email strianop@gmail.comAbstract: Lennox-Gastaut syndrome (LGS) is a severe, childhood-onset, developmental epileptic encephalopathy, with different etiologies and co-morbidities. Seizure treatment in LGS represents a major challenge; new antiepileptic drugs (AEDs) are developed to especially address seizures resulting in high morbidity and mortality, such as drop seizures. Rufinamide (RFN) is one of the latest AEDs licensed for patients with LGS. Its mechanism of action involves sodium channels in a way that is unrelated to other AEDs. Here we discuss the use of adjunctive RFN in children and adolescents with LGS and its efficacy and safety profile, based on a systematic literature review. RFN shows a very favorable profile in terms of adverse events and drug-interactions in children. It is particularly effective on tonic-atonic seizures and spasms, impacting on the quality of life of the patients. Further studies are needed to clarify the interaction profile with the newest AEDs for LGS and to assess correlations between the etiology of LGS and drug response to individualize treatment and maximize efficacy.Keywords: rufinamide, Lennox-Gastaut, epilepsy, childrenBalagura GRiva AMarchese FVerrotti AStriano PDove Medical Pressarticlerufinamidelennox-gastautepilepsychildrenNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 369-379 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rufinamide lennox-gastaut epilepsy children Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	rufinamide lennox-gastaut epilepsy children Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Balagura G Riva A Marchese F Verrotti A Striano P Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
description	Ganna Balagura,1,2 Antonella Riva,2 Francesca Marchese,2 Alberto Verrotti,3 Pasquale Striano1,2 1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa, Genoa, Italy; 2Pediatric Neurology and Muscular Diseases Unit, IRCCS ‘G. Gaslini’ Institute, Genoa, Italy; 3Department of Pediatrics, University of L’Aquila, L’Aquila, ItalyCorrespondence: Pasquale Striano Email strianop@gmail.comAbstract: Lennox-Gastaut syndrome (LGS) is a severe, childhood-onset, developmental epileptic encephalopathy, with different etiologies and co-morbidities. Seizure treatment in LGS represents a major challenge; new antiepileptic drugs (AEDs) are developed to especially address seizures resulting in high morbidity and mortality, such as drop seizures. Rufinamide (RFN) is one of the latest AEDs licensed for patients with LGS. Its mechanism of action involves sodium channels in a way that is unrelated to other AEDs. Here we discuss the use of adjunctive RFN in children and adolescents with LGS and its efficacy and safety profile, based on a systematic literature review. RFN shows a very favorable profile in terms of adverse events and drug-interactions in children. It is particularly effective on tonic-atonic seizures and spasms, impacting on the quality of life of the patients. Further studies are needed to clarify the interaction profile with the newest AEDs for LGS and to assess correlations between the etiology of LGS and drug response to individualize treatment and maximize efficacy.Keywords: rufinamide, Lennox-Gastaut, epilepsy, children
format	article
author	Balagura G Riva A Marchese F Verrotti A Striano P
author_facet	Balagura G Riva A Marchese F Verrotti A Striano P
author_sort	Balagura G
title	Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
title_short	Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
title_full	Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
title_fullStr	Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
title_full_unstemmed	Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
title_sort	adjunctive rufinamide in children with lennox-gastaut syndrome: a literature review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/150e9af6e1924893a4ea1ddfc95c12ff
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Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review

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