Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.

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Autores principales:	Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michael Graf, Stefan Arenz, Maha Abdelshahid, Britta Seip, Helmut Grubmüller, Alexander S. Mankin, C. Axel Innis, Nora Vázquez-Laslop, Daniel N. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15117e74a84f4129bf14254d7d049216
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spelling	oai:doaj.org-article:15117e74a84f4129bf14254d7d0492162021-12-02T16:26:40ZStructural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics10.1038/s41467-021-24674-92041-1723https://doaj.org/article/15117e74a84f4129bf14254d7d0492162021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24674-9https://doaj.org/toc/2041-1723Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.Bertrand BeckertElodie C. LeroyShanmugapriya SothiselvamLars V. BockMaxim S. SvetlovMichael GrafStefan ArenzMaha AbdelshahidBritta SeipHelmut GrubmüllerAlexander S. MankinC. Axel InnisNora Vázquez-LaslopDaniel N. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bertrand Beckert Elodie C. Leroy Shanmugapriya Sothiselvam Lars V. Bock Maxim S. Svetlov Michael Graf Stefan Arenz Maha Abdelshahid Britta Seip Helmut Grubmüller Alexander S. Mankin C. Axel Innis Nora Vázquez-Laslop Daniel N. Wilson Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
description	Macrolides and ketolides antibiotics selectively interfere with the translation of a specific subset of proteins. Here the authors show how the macrolide erythromycin and the ketolide telithromycin interplay with the nascent polypeptide chain to arrest translation.
format	article
author	Bertrand Beckert Elodie C. Leroy Shanmugapriya Sothiselvam Lars V. Bock Maxim S. Svetlov Michael Graf Stefan Arenz Maha Abdelshahid Britta Seip Helmut Grubmüller Alexander S. Mankin C. Axel Innis Nora Vázquez-Laslop Daniel N. Wilson
author_facet	Bertrand Beckert Elodie C. Leroy Shanmugapriya Sothiselvam Lars V. Bock Maxim S. Svetlov Michael Graf Stefan Arenz Maha Abdelshahid Britta Seip Helmut Grubmüller Alexander S. Mankin C. Axel Innis Nora Vázquez-Laslop Daniel N. Wilson
author_sort	Bertrand Beckert
title	Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
title_short	Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
title_full	Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
title_fullStr	Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
title_full_unstemmed	Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
title_sort	structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/15117e74a84f4129bf14254d7d049216
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Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

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