The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation

The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation

PurposeGenome-wide association studies have identified numerous genetic variants that are associated with osteoporosis risk; however, most of them are present in the non-coding regions of the genome and the functional mechanisms are unknown. In this study, we aimed to investigate the potential varia...

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Autores principales: Dung-Jang Tsai, Wen-Hui Fang, Li-Wei Wu, Ming-Cheng Tai, Chung-Cheng Kao, Shih-Ming Huang, Wei-Teing Chen, Po-Jen Hsiao, Chih-Chien Chiu, Wen Su, Chia-Chun Wu, Sui-Lung Su
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
osteoporosis
runt domain transcription factor 2
binding site polymorphism
case-control study
PLCB4
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Acceso en línea:https://doaj.org/article/151779b9018e43be8003a99816e486cd
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