CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Abstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be...

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Autores principales:	M. V. Zykov, O. L. Barbarash, V. V. Kashtalap, A. V. Veremeev, L. S. Barbarash
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	coronary vessels atherosclerosis inflammation markers il-12 diagnostic significance Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1519a2b5f04345f3a7deb12a78063bf1
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spelling	oai:doaj.org-article:1519a2b5f04345f3a7deb12a78063bf12021-11-18T08:03:41ZCLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION1563-06252313-741X10.15789/1563-0625-2011-2-3-219-226https://doaj.org/article/1519a2b5f04345f3a7deb12a78063bf12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/471https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be significantly increased in the patients with multi-vesselcoronary artery disease, as compared to the patients with single coronary lesions. A positive correlation was revealed between the levels of IL-12 and IL-6 inflammation markers, and severity of atherosclerotic lesions of non-coronary arteries (brachiocephalic vessels, or lower limb arteries). Regression analysis, using an iterative approach, showed that patients’ age of ≥ 53 years and IL-12 levels ≥ 87.1 pg/ml are of highest predictive value, when detecting clinically significant coronary lesions. Meanwhile, the age of ≥ 65 years and IL- 12 levels exceeding 108.8 pg/ml allow of detecting haemodynamically significant non-coronary lesions. Acute heart failure according to Killip class II and more, and IL-12 levels over 90 pg/ml have been verified as independent variables for risk stratification of any cardiovascular event within a year after MI. Hence, among all studied inflammatory indexes, IL-12 possesses the greatest diagnostic value in defining patients at a high risk for severe coronary and multifocal atherosclerosis and subsequent complications. (Med. Immunol., 2011, vol. 13, N 2-3, pp 219-226)M. V. ZykovO. L. BarbarashV. V. KashtalapA. V. VeremeevL. S. BarbarashSPb RAACIarticlecoronary vesselsatherosclerosisinflammation markersil-12diagnostic significanceImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 219-226 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	coronary vessels atherosclerosis inflammation markers il-12 diagnostic significance Immunologic diseases. Allergy RC581-607
spellingShingle	coronary vessels atherosclerosis inflammation markers il-12 diagnostic significance Immunologic diseases. Allergy RC581-607 M. V. Zykov O. L. Barbarash V. V. Kashtalap A. V. Veremeev L. S. Barbarash CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
description	Abstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be significantly increased in the patients with multi-vesselcoronary artery disease, as compared to the patients with single coronary lesions. A positive correlation was revealed between the levels of IL-12 and IL-6 inflammation markers, and severity of atherosclerotic lesions of non-coronary arteries (brachiocephalic vessels, or lower limb arteries). Regression analysis, using an iterative approach, showed that patients’ age of ≥ 53 years and IL-12 levels ≥ 87.1 pg/ml are of highest predictive value, when detecting clinically significant coronary lesions. Meanwhile, the age of ≥ 65 years and IL- 12 levels exceeding 108.8 pg/ml allow of detecting haemodynamically significant non-coronary lesions. Acute heart failure according to Killip class II and more, and IL-12 levels over 90 pg/ml have been verified as independent variables for risk stratification of any cardiovascular event within a year after MI. Hence, among all studied inflammatory indexes, IL-12 possesses the greatest diagnostic value in defining patients at a high risk for severe coronary and multifocal atherosclerosis and subsequent complications. (Med. Immunol., 2011, vol. 13, N 2-3, pp 219-226)
format	article
author	M. V. Zykov O. L. Barbarash V. V. Kashtalap A. V. Veremeev L. S. Barbarash
author_facet	M. V. Zykov O. L. Barbarash V. V. Kashtalap A. V. Veremeev L. S. Barbarash
author_sort	M. V. Zykov
title	CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_short	CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_full	CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_fullStr	CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_full_unstemmed	CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_sort	clinical and prognostic value of interleukin-12 in patients with acute myocardial infarction
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1519a2b5f04345f3a7deb12a78063bf1
work_keys_str_mv	AT mvzykov clinicalandprognosticvalueofinterleukin12inpatientswithacutemyocardialinfarction AT olbarbarash clinicalandprognosticvalueofinterleukin12inpatientswithacutemyocardialinfarction AT vvkashtalap clinicalandprognosticvalueofinterleukin12inpatientswithacutemyocardialinfarction AT avveremeev clinicalandprognosticvalueofinterleukin12inpatientswithacutemyocardialinfarction AT lsbarbarash clinicalandprognosticvalueofinterleukin12inpatientswithacutemyocardialinfarction
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CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

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