The Skin Microbiome of Cohabiting Couples

ABSTRACT Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impac...

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Autores principales:	Ashley A. Ross, Andrew C. Doxey, Josh D. Neufeld
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	cohabitation high-throughput sequencing human skin microbiome random forest modeling Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/151c096292b54150b8ce0095c244a464
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spelling	oai:doaj.org-article:151c096292b54150b8ce0095c244a4642021-12-02T19:45:30ZThe Skin Microbiome of Cohabiting Couples10.1128/mSystems.00043-172379-5077https://doaj.org/article/151c096292b54150b8ce0095c244a4642017-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00043-17https://doaj.org/toc/2379-5077ABSTRACT Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impacts an individual’s skin microbiome, leading to shared skin microbiota among partner pairs. Amplified 16S rRNA genes of bacteria and archaea from a total of 340 skin swabs were analyzed by high-throughput sequencing, and the results demonstrated that cohabitation was significantly associated with microbial community composition, although this association was greatly exceeded by characteristics of body location and individuality. Random forest modeling demonstrated that the partners could be predicted 86% of the time (P < 0.001) based on their skin microbiome profiles, which was always greater than combinations of incorrectly matched partners. Cohabiting couples had the most similar overall microbial skin communities on their feet, according to Bray-Curtis distances. In contrast, thigh microbial communities were strongly associated with biological sex rather than cohabiting partner. Additional factors that were associated with the skin microbiome of specific body locations included the use of skin care products, pet ownership, allergies, and alcohol consumption. These baseline data identified links between the skin microbiome and daily interactions among cohabiting individuals, adding to known factors that shape the human microbiome and, by extension, its relation to human health. IMPORTANCE Our work characterizes the influence of cohabitation as a factor influencing the composition of the skin microbiome. Although the body site and sampled individual were stronger influences than other factors collected as metadata in this study, we show that modeling of detected microbial taxa can help with correct identifications of cohabiting partners based on skin microbiome profiles using machine learning approaches. These results show that a cohabiting partner can significantly influence our microbiota. Follow-up studies will be important for investigating the implications of shared microbiota on dermatological health and the contributions of cohabiting parents to the microbiome profiles of their infants.Ashley A. RossAndrew C. DoxeyJosh D. NeufeldAmerican Society for Microbiologyarticlecohabitationhigh-throughput sequencinghuman skinmicrobiomerandom forest modelingMicrobiologyQR1-502ENmSystems, Vol 2, Iss 4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cohabitation high-throughput sequencing human skin microbiome random forest modeling Microbiology QR1-502
spellingShingle	cohabitation high-throughput sequencing human skin microbiome random forest modeling Microbiology QR1-502 Ashley A. Ross Andrew C. Doxey Josh D. Neufeld The Skin Microbiome of Cohabiting Couples
description	ABSTRACT Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impacts an individual’s skin microbiome, leading to shared skin microbiota among partner pairs. Amplified 16S rRNA genes of bacteria and archaea from a total of 340 skin swabs were analyzed by high-throughput sequencing, and the results demonstrated that cohabitation was significantly associated with microbial community composition, although this association was greatly exceeded by characteristics of body location and individuality. Random forest modeling demonstrated that the partners could be predicted 86% of the time (P < 0.001) based on their skin microbiome profiles, which was always greater than combinations of incorrectly matched partners. Cohabiting couples had the most similar overall microbial skin communities on their feet, according to Bray-Curtis distances. In contrast, thigh microbial communities were strongly associated with biological sex rather than cohabiting partner. Additional factors that were associated with the skin microbiome of specific body locations included the use of skin care products, pet ownership, allergies, and alcohol consumption. These baseline data identified links between the skin microbiome and daily interactions among cohabiting individuals, adding to known factors that shape the human microbiome and, by extension, its relation to human health. IMPORTANCE Our work characterizes the influence of cohabitation as a factor influencing the composition of the skin microbiome. Although the body site and sampled individual were stronger influences than other factors collected as metadata in this study, we show that modeling of detected microbial taxa can help with correct identifications of cohabiting partners based on skin microbiome profiles using machine learning approaches. These results show that a cohabiting partner can significantly influence our microbiota. Follow-up studies will be important for investigating the implications of shared microbiota on dermatological health and the contributions of cohabiting parents to the microbiome profiles of their infants.
format	article
author	Ashley A. Ross Andrew C. Doxey Josh D. Neufeld
author_facet	Ashley A. Ross Andrew C. Doxey Josh D. Neufeld
author_sort	Ashley A. Ross
title	The Skin Microbiome of Cohabiting Couples
title_short	The Skin Microbiome of Cohabiting Couples
title_full	The Skin Microbiome of Cohabiting Couples
title_fullStr	The Skin Microbiome of Cohabiting Couples
title_full_unstemmed	The Skin Microbiome of Cohabiting Couples
title_sort	skin microbiome of cohabiting couples
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/151c096292b54150b8ce0095c244a464
work_keys_str_mv	AT ashleyaross theskinmicrobiomeofcohabitingcouples AT andrewcdoxey theskinmicrobiomeofcohabitingcouples AT joshdneufeld theskinmicrobiomeofcohabitingcouples AT ashleyaross skinmicrobiomeofcohabitingcouples AT andrewcdoxey skinmicrobiomeofcohabitingcouples AT joshdneufeld skinmicrobiomeofcohabitingcouples
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The Skin Microbiome of Cohabiting Couples

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