A defined subunit vaccine that protects against vector-borne visceral leishmaniasis

Leishmaniasis: Improved vaccine candidate demonstrates protection A research collaboration between the United States and Bangladesh has improved its own vaccine candidate and demonstrated it to be effective. The vaccine’s target, visceral leishmaniasis, is a deadly parasitic disease transmitted via...

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Autores principales:	Malcolm S. Duthie, Lais Pereira, Michelle Favila, Kimberly A. Hofmeyer, S. Jim Reed, Sonia Metangmo, Shannon Townsend, John D. Laurance, Alessandro Picone, Ayesha Misquith, Faria Hossain, Prakash Ghosh, Md Anik Ashfaq Khan, Jeffery Guderian, H. Remy Bailor, Hong Liang, Julie Vergara, Fabiano Oliveira, Randall F. Howard, Shaden Kamhawi, Dinesh Mondal, Rhea N. Coler, Jesus G. Valenzuela, Steven G. Reed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1521212ea78c4b1fba37c36cea70ce62
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spelling	oai:doaj.org-article:1521212ea78c4b1fba37c36cea70ce622021-12-02T16:20:00ZA defined subunit vaccine that protects against vector-borne visceral leishmaniasis10.1038/s41541-017-0025-52059-0105https://doaj.org/article/1521212ea78c4b1fba37c36cea70ce622017-08-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0025-5https://doaj.org/toc/2059-0105Leishmaniasis: Improved vaccine candidate demonstrates protection A research collaboration between the United States and Bangladesh has improved its own vaccine candidate and demonstrated it to be effective. The vaccine’s target, visceral leishmaniasis, is a deadly parasitic disease transmitted via the bites of sandflies. The collaboration, led by Steven Reed of the United States’ Infectious Disease Research Institute, previously developed a vaccine that presents two parasite-derived proteins (antigens) to a host’s immune system, allowing it to build a defense. The new vaccine candidate contains three antigens and has shown to confer disease resistance to hamsters who were subsequently exposed to infected sandflies. This is the first time a vaccine for visceral leishmaniasis has stood up in tests where the host has been infected through natural methods, which inspires confidence in the vaccine’s capacity to work in the wild.Malcolm S. DuthieLais PereiraMichelle FavilaKimberly A. HofmeyerS. Jim ReedSonia MetangmoShannon TownsendJohn D. LauranceAlessandro PiconeAyesha MisquithFaria HossainPrakash GhoshMd Anik Ashfaq KhanJeffery GuderianH. Remy BailorHong LiangJulie VergaraFabiano OliveiraRandall F. HowardShaden KamhawiDinesh MondalRhea N. ColerJesus G. ValenzuelaSteven G. ReedNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Malcolm S. Duthie Lais Pereira Michelle Favila Kimberly A. Hofmeyer S. Jim Reed Sonia Metangmo Shannon Townsend John D. Laurance Alessandro Picone Ayesha Misquith Faria Hossain Prakash Ghosh Md Anik Ashfaq Khan Jeffery Guderian H. Remy Bailor Hong Liang Julie Vergara Fabiano Oliveira Randall F. Howard Shaden Kamhawi Dinesh Mondal Rhea N. Coler Jesus G. Valenzuela Steven G. Reed A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
description	Leishmaniasis: Improved vaccine candidate demonstrates protection A research collaboration between the United States and Bangladesh has improved its own vaccine candidate and demonstrated it to be effective. The vaccine’s target, visceral leishmaniasis, is a deadly parasitic disease transmitted via the bites of sandflies. The collaboration, led by Steven Reed of the United States’ Infectious Disease Research Institute, previously developed a vaccine that presents two parasite-derived proteins (antigens) to a host’s immune system, allowing it to build a defense. The new vaccine candidate contains three antigens and has shown to confer disease resistance to hamsters who were subsequently exposed to infected sandflies. This is the first time a vaccine for visceral leishmaniasis has stood up in tests where the host has been infected through natural methods, which inspires confidence in the vaccine’s capacity to work in the wild.
format	article
author	Malcolm S. Duthie Lais Pereira Michelle Favila Kimberly A. Hofmeyer S. Jim Reed Sonia Metangmo Shannon Townsend John D. Laurance Alessandro Picone Ayesha Misquith Faria Hossain Prakash Ghosh Md Anik Ashfaq Khan Jeffery Guderian H. Remy Bailor Hong Liang Julie Vergara Fabiano Oliveira Randall F. Howard Shaden Kamhawi Dinesh Mondal Rhea N. Coler Jesus G. Valenzuela Steven G. Reed
author_facet	Malcolm S. Duthie Lais Pereira Michelle Favila Kimberly A. Hofmeyer S. Jim Reed Sonia Metangmo Shannon Townsend John D. Laurance Alessandro Picone Ayesha Misquith Faria Hossain Prakash Ghosh Md Anik Ashfaq Khan Jeffery Guderian H. Remy Bailor Hong Liang Julie Vergara Fabiano Oliveira Randall F. Howard Shaden Kamhawi Dinesh Mondal Rhea N. Coler Jesus G. Valenzuela Steven G. Reed
author_sort	Malcolm S. Duthie
title	A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
title_short	A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
title_full	A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
title_fullStr	A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
title_full_unstemmed	A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
title_sort	defined subunit vaccine that protects against vector-borne visceral leishmaniasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1521212ea78c4b1fba37c36cea70ce62
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A defined subunit vaccine that protects against vector-borne visceral leishmaniasis

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