IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS

A comparative in vitro study of blood mononuclear cells from multiple sclerosis patients and healthy donors was performed, in order to evaluate proliferative response to a retroviral antigen, aiming to determine immunomodulatory properties of synthetic oligopeptide homologous to a highly conserved h...

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Autores principales:	A. A. Smagin, I. A. Goldina, K. V. Gaidul, M. S. Lubarsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	endogenous retroviruses oligopeptide blood mononuclears mitogenic effect multiple sclerosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1522a6cf71e54b86b7e73d248a43d79f
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spelling	oai:doaj.org-article:1522a6cf71e54b86b7e73d248a43d79f2021-11-18T08:03:44ZIN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS1563-06252313-741X10.15789/1563-0625-2014-3-247-256https://doaj.org/article/1522a6cf71e54b86b7e73d248a43d79f2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/690https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA comparative in vitro study of blood mononuclear cells from multiple sclerosis patients and healthy donors was performed, in order to evaluate proliferative response to a retroviral antigen, aiming to determine immunomodulatory properties of synthetic oligopeptide homologous to a highly conserved human endogenous retrovirus HERV-Eλ4-1 envelope protein. It was revealed that this oligopeptide is able to stimulate the in vitro spontaneous and mitogen-induced proliferation of blood mononuclear cells from either donor and multiple sclerosis patients. Intensity of this oligopeptide-induced stimulatory effect depends on the protein concentration, and on initial level of blood immunocompetent cells proliferation. Hence, the endogenous retrovirus HERV-Eλ4-1 envelope region protein is able to increase functional activity of immunocompetent cells from human blood, that suggesting its immunostimulatory properties. It is possible that the mitogenic effects of this protein upon immunocompetent cells of multiple sclerosis patients represent a potential mechanism of retroviral involvement into pathogenesis of the disorder.A. A. SmaginI. A. GoldinaK. V. GaidulM. S. LubarskySPb RAACIarticleendogenous retrovirusesoligopeptideblood mononuclearsmitogenic effectmultiple sclerosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 247-256 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	endogenous retroviruses oligopeptide blood mononuclears mitogenic effect multiple sclerosis Immunologic diseases. Allergy RC581-607
spellingShingle	endogenous retroviruses oligopeptide blood mononuclears mitogenic effect multiple sclerosis Immunologic diseases. Allergy RC581-607 A. A. Smagin I. A. Goldina K. V. Gaidul M. S. Lubarsky IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS
description	A comparative in vitro study of blood mononuclear cells from multiple sclerosis patients and healthy donors was performed, in order to evaluate proliferative response to a retroviral antigen, aiming to determine immunomodulatory properties of synthetic oligopeptide homologous to a highly conserved human endogenous retrovirus HERV-Eλ4-1 envelope protein. It was revealed that this oligopeptide is able to stimulate the in vitro spontaneous and mitogen-induced proliferation of blood mononuclear cells from either donor and multiple sclerosis patients. Intensity of this oligopeptide-induced stimulatory effect depends on the protein concentration, and on initial level of blood immunocompetent cells proliferation. Hence, the endogenous retrovirus HERV-Eλ4-1 envelope region protein is able to increase functional activity of immunocompetent cells from human blood, that suggesting its immunostimulatory properties. It is possible that the mitogenic effects of this protein upon immunocompetent cells of multiple sclerosis patients represent a potential mechanism of retroviral involvement into pathogenesis of the disorder.
format	article
author	A. A. Smagin I. A. Goldina K. V. Gaidul M. S. Lubarsky
author_facet	A. A. Smagin I. A. Goldina K. V. Gaidul M. S. Lubarsky
author_sort	A. A. Smagin
title	IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS
title_short	IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS
title_full	IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS
title_fullStr	IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS
title_full_unstemmed	IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS
title_sort	in vitro induction of blood mononuclear cell proliferation by endogenous retroviral herv-eλ4-1 envelope peptide in patients with multiple sclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1522a6cf71e54b86b7e73d248a43d79f
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IN VITRO INDUCTION OF BLOOD MONONUCLEAR CELL PROLIFERATION BY ENDOGENOUS RETROVIRAL HERV-Eλ4-1 ENVELOPE PEPTIDE IN PATIENTS WITH MULTIPLE SCLEROSIS

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