Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podo...

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Autores principales: Carole Henique, Guillaume Bollée, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Léa Guyonnet, François Gaillard, Hélène Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legrès, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B. Huber, Laurent Mesnard, Olivia Lenoir, Pierre-Louis Tharaux
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/15231f9316144012af77e188917d3a47
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spelling oai:doaj.org-article:15231f9316144012af77e188917d3a472021-12-02T17:06:17ZGenetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis10.1038/s41467-017-01885-72041-1723https://doaj.org/article/15231f9316144012af77e188917d3a472017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01885-7https://doaj.org/toc/2041-1723Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.Carole HeniqueGuillaume BolléeXavier LoyerFlorian GrahammerNeeraj DhaunMarine CamusJulien VernereyLéa GuyonnetFrançois GaillardHélène LazarethCharlotte MeyerImane BensaadaLuc LegrèsTakashi SatohShizuo AkiraPatrick BrunevalStefanie DimmelerAlain TedguiAlexandre KarrasEric ThervetDominique NochyTobias B. HuberLaurent MesnardOlivia LenoirPierre-Louis TharauxNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Carole Henique
Guillaume Bollée
Xavier Loyer
Florian Grahammer
Neeraj Dhaun
Marine Camus
Julien Vernerey
Léa Guyonnet
François Gaillard
Hélène Lazareth
Charlotte Meyer
Imane Bensaada
Luc Legrès
Takashi Satoh
Shizuo Akira
Patrick Bruneval
Stefanie Dimmeler
Alain Tedgui
Alexandre Karras
Eric Thervet
Dominique Nochy
Tobias B. Huber
Laurent Mesnard
Olivia Lenoir
Pierre-Louis Tharaux
Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
description Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.
format article
author Carole Henique
Guillaume Bollée
Xavier Loyer
Florian Grahammer
Neeraj Dhaun
Marine Camus
Julien Vernerey
Léa Guyonnet
François Gaillard
Hélène Lazareth
Charlotte Meyer
Imane Bensaada
Luc Legrès
Takashi Satoh
Shizuo Akira
Patrick Bruneval
Stefanie Dimmeler
Alain Tedgui
Alexandre Karras
Eric Thervet
Dominique Nochy
Tobias B. Huber
Laurent Mesnard
Olivia Lenoir
Pierre-Louis Tharaux
author_facet Carole Henique
Guillaume Bollée
Xavier Loyer
Florian Grahammer
Neeraj Dhaun
Marine Camus
Julien Vernerey
Léa Guyonnet
François Gaillard
Hélène Lazareth
Charlotte Meyer
Imane Bensaada
Luc Legrès
Takashi Satoh
Shizuo Akira
Patrick Bruneval
Stefanie Dimmeler
Alain Tedgui
Alexandre Karras
Eric Thervet
Dominique Nochy
Tobias B. Huber
Laurent Mesnard
Olivia Lenoir
Pierre-Louis Tharaux
author_sort Carole Henique
title Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
title_short Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
title_full Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
title_fullStr Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
title_full_unstemmed Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
title_sort genetic and pharmacological inhibition of microrna-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/15231f9316144012af77e188917d3a47
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