Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.

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Bibliographic Details
Main Authors:	Shefeeq M. Theparambil, Patrick S. Hosford, Iván Ruminot, Olga Kopach, James R. Reynolds, Pamela Y. Sandoval, Dmitri A. Rusakov, L. Felipe Barros, Alexander V. Gourine
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
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id	oai:doaj.org-article:1524bdcca8db439a89cd7a17717a5a6c
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spelling	oai:doaj.org-article:1524bdcca8db439a89cd7a17717a5a6c2021-12-02T18:37:29ZAstrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle10.1038/s41467-020-18756-32041-1723https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18756-3https://doaj.org/toc/2041-1723Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.Shefeeq M. TheparambilPatrick S. HosfordIván RuminotOlga KopachJames R. ReynoldsPamela Y. SandovalDmitri A. RusakovL. Felipe BarrosAlexander V. GourineNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shefeeq M. Theparambil Patrick S. Hosford Iván Ruminot Olga Kopach James R. Reynolds Pamela Y. Sandoval Dmitri A. Rusakov L. Felipe Barros Alexander V. Gourine Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
description	Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.
format	article
author	Shefeeq M. Theparambil Patrick S. Hosford Iván Ruminot Olga Kopach James R. Reynolds Pamela Y. Sandoval Dmitri A. Rusakov L. Felipe Barros Alexander V. Gourine
author_facet	Shefeeq M. Theparambil Patrick S. Hosford Iván Ruminot Olga Kopach James R. Reynolds Pamela Y. Sandoval Dmitri A. Rusakov L. Felipe Barros Alexander V. Gourine
author_sort	Shefeeq M. Theparambil
title	Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_short	Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_full	Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_fullStr	Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_full_unstemmed	Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_sort	astrocytes regulate brain extracellular ph via a neuronal activity-dependent bicarbonate shuttle
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
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Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

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