Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.

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Autores principales: Shefeeq M. Theparambil, Patrick S. Hosford, Iván Ruminot, Olga Kopach, James R. Reynolds, Pamela Y. Sandoval, Dmitri A. Rusakov, L. Felipe Barros, Alexander V. Gourine
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
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spelling oai:doaj.org-article:1524bdcca8db439a89cd7a17717a5a6c2021-12-02T18:37:29ZAstrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle10.1038/s41467-020-18756-32041-1723https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18756-3https://doaj.org/toc/2041-1723Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.Shefeeq M. TheparambilPatrick S. HosfordIván RuminotOlga KopachJames R. ReynoldsPamela Y. SandovalDmitri A. RusakovL. Felipe BarrosAlexander V. GourineNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shefeeq M. Theparambil
Patrick S. Hosford
Iván Ruminot
Olga Kopach
James R. Reynolds
Pamela Y. Sandoval
Dmitri A. Rusakov
L. Felipe Barros
Alexander V. Gourine
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
description Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.
format article
author Shefeeq M. Theparambil
Patrick S. Hosford
Iván Ruminot
Olga Kopach
James R. Reynolds
Pamela Y. Sandoval
Dmitri A. Rusakov
L. Felipe Barros
Alexander V. Gourine
author_facet Shefeeq M. Theparambil
Patrick S. Hosford
Iván Ruminot
Olga Kopach
James R. Reynolds
Pamela Y. Sandoval
Dmitri A. Rusakov
L. Felipe Barros
Alexander V. Gourine
author_sort Shefeeq M. Theparambil
title Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_short Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_full Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_fullStr Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_full_unstemmed Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
title_sort astrocytes regulate brain extracellular ph via a neuronal activity-dependent bicarbonate shuttle
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
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AT patrickshosford astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT ivanruminot astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT olgakopach astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT jamesrreynolds astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT pamelaysandoval astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT dmitriarusakov astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT lfelipebarros astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
AT alexandervgourine astrocytesregulatebrainextracellularphviaaneuronalactivitydependentbicarbonateshuttle
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