Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.
Guardado en:
Autores principales: | Shefeeq M. Theparambil, Patrick S. Hosford, Iván Ruminot, Olga Kopach, James R. Reynolds, Pamela Y. Sandoval, Dmitri A. Rusakov, L. Felipe Barros, Alexander V. Gourine |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity
por: Shahriar Sheikhbahaei, et al.
Publicado: (2018) -
Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling
por: Jun Yin, et al.
Publicado: (2021) -
Astrocytic GABA transporter activity modulates excitatory neurotransmission
por: Kim Boddum, et al.
Publicado: (2016) -
Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms
por: Sasha J. Rose, et al.
Publicado: (2016) -
The time to peak blood bicarbonate (HCO3-), pH, and the strong ion difference (SID) following sodium bicarbonate (NaHCO3) ingestion in highly trained adolescent swimmers.
por: Josh W Newbury, et al.
Publicado: (2021)