Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.

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Auteurs principaux: Shefeeq M. Theparambil, Patrick S. Hosford, Iván Ruminot, Olga Kopach, James R. Reynolds, Pamela Y. Sandoval, Dmitri A. Rusakov, L. Felipe Barros, Alexander V. Gourine
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/1524bdcca8db439a89cd7a17717a5a6c
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