Health benefits of late-onset metformin treatment every other week in mice
Intermittent use of metformin improves healthspan in old mice Chronic daily exposure to a high dose of metformin (e.g., 1% w/w) shortens lifespan of non-diabetic mice, although in the short term this treatment confers a similar pattern of gene expression and phenotypes consistent with the benefits o...
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Nature Portfolio
2017
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oai:doaj.org-article:152539cd501d45ffb8c1f8e7c9698a5c2021-12-02T16:05:42ZHealth benefits of late-onset metformin treatment every other week in mice10.1038/s41514-017-0018-72056-3973https://doaj.org/article/152539cd501d45ffb8c1f8e7c9698a5c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0018-7https://doaj.org/toc/2056-3973Intermittent use of metformin improves healthspan in old mice Chronic daily exposure to a high dose of metformin (e.g., 1% w/w) shortens lifespan of non-diabetic mice, although in the short term this treatment confers a similar pattern of gene expression and phenotypes consistent with the benefits of caloric restriction. A team of researchers led by Rafael de Cabo at the National Institute on Aging, NIH tested whether a strategy of intermittent 1% metformin treatment in old mice alters the course of aging and avoids toxicity. They found that when metformin was given every-other-week, it significantly improved insulin sensitivity and reduced age-associated liver lesions without having a negative impact on maximum lifespan in male mice. The absence of adverse outcomes associated with the use of 1% metformin in old mice has clinical translatability into the biology of aging in humans.Irene AlfarasSarah J. MitchellHector MoraDarisbeth Rosario LugoAlessandra WarrenIgnacio Navas-EnamoradoVickie HoffmannChristopher HineJames R. MitchellDavid G. Le CouteurVictoria C. CoggerMichel BernierRafael de CaboNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-13 (2017) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Geriatrics RC952-954.6 |
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Geriatrics RC952-954.6 Irene Alfaras Sarah J. Mitchell Hector Mora Darisbeth Rosario Lugo Alessandra Warren Ignacio Navas-Enamorado Vickie Hoffmann Christopher Hine James R. Mitchell David G. Le Couteur Victoria C. Cogger Michel Bernier Rafael de Cabo Health benefits of late-onset metformin treatment every other week in mice |
| description |
Intermittent use of metformin improves healthspan in old mice Chronic daily exposure to a high dose of metformin (e.g., 1% w/w) shortens lifespan of non-diabetic mice, although in the short term this treatment confers a similar pattern of gene expression and phenotypes consistent with the benefits of caloric restriction. A team of researchers led by Rafael de Cabo at the National Institute on Aging, NIH tested whether a strategy of intermittent 1% metformin treatment in old mice alters the course of aging and avoids toxicity. They found that when metformin was given every-other-week, it significantly improved insulin sensitivity and reduced age-associated liver lesions without having a negative impact on maximum lifespan in male mice. The absence of adverse outcomes associated with the use of 1% metformin in old mice has clinical translatability into the biology of aging in humans. |
| format |
article |
| author |
Irene Alfaras Sarah J. Mitchell Hector Mora Darisbeth Rosario Lugo Alessandra Warren Ignacio Navas-Enamorado Vickie Hoffmann Christopher Hine James R. Mitchell David G. Le Couteur Victoria C. Cogger Michel Bernier Rafael de Cabo |
| author_facet |
Irene Alfaras Sarah J. Mitchell Hector Mora Darisbeth Rosario Lugo Alessandra Warren Ignacio Navas-Enamorado Vickie Hoffmann Christopher Hine James R. Mitchell David G. Le Couteur Victoria C. Cogger Michel Bernier Rafael de Cabo |
| author_sort |
Irene Alfaras |
| title |
Health benefits of late-onset metformin treatment every other week in mice |
| title_short |
Health benefits of late-onset metformin treatment every other week in mice |
| title_full |
Health benefits of late-onset metformin treatment every other week in mice |
| title_fullStr |
Health benefits of late-onset metformin treatment every other week in mice |
| title_full_unstemmed |
Health benefits of late-onset metformin treatment every other week in mice |
| title_sort |
health benefits of late-onset metformin treatment every other week in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/152539cd501d45ffb8c1f8e7c9698a5c |
| work_keys_str_mv |
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